Adolescent C57BL/6J (but not DBA/2J) mice consume greater amounts of limited-access ethanol compared to adults and display continued elevated ethanol intake into adulthood.

Alcoholism, Clinical and Experimental Research
E M MooreS L Boehm

Abstract

Alcohol use is common during the adolescent period, a time at which a number of crucial neurobiological, hormonal, and behavioral changes occur (Spear, 2000). In order to more fully understand the complex interaction between alcohol use and these age-typical neurobiological changes, animal models must be utilized. Rodents experience a developmental period similar to that of adolescence. Although rat models have shown striking adolescent-specific differences in sensitivity to ethanol, little work has been done in mice despite the fact that the C57BL/6J (B6) and DBA2/J (D2) mice have been shown to markedly differ in ethanol preference drinking and exhibit widely different sensitivities to ethanol. The current study examined ethanol intake in adolescent and adult B6 and D2 mice using a limited access alcohol exposure paradigm called Drinking in the Dark (DID). Additionally, the effect of adolescent (or adult) ethanol exposure on subsequent adult ethanol intake was examined by re-exposing the mice to the same paradigm once the adolescents reached adulthood. We hypothesized that adolescent (P25-45) mice would exhibit greater binge-like alcohol intake compared to adults (P60-80), and that B6 mice would exhibit greater binge-like alco...Continue Reading

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Citations

Feb 3, 2016·Alcoholism, Clinical and Experimental Research·Caroline Quoilin, Stephen L Boehm
Jan 10, 2012·Behavioural Brain Research·Caroline QuoilinEtienne Quertemont
Jul 6, 2010·Neuropharmacology·Leandro F VendruscoloMartine Cador
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Jan 3, 2013·Alcoholism, Clinical and Experimental Research·Margaret BroadwaterLinda P Spear
Jul 1, 2010·Alcoholism, Clinical and Experimental Research·Nympha B D'Souza El-GuindyGary G Meadows
Mar 1, 2011·Alcoholism, Clinical and Experimental Research·Margaret BroadwaterLinda P Spear
Mar 22, 2012·Alcoholism, Clinical and Experimental Research·Chiming HuangRosa Huang
Jun 15, 2013·Alcoholism, Clinical and Experimental Research·Dennis R SpartaAntonello Bonci
Feb 24, 2015·Alcoholism, Clinical and Experimental Research·James M Doherty, Rueben A Gonzales
Mar 1, 2014·Alcoholism, Clinical and Experimental Research·Debra K CozzoliDeborah A Finn
Jan 22, 2013·Pharmacology, Biochemistry, and Behavior·Laverne C MelónStephen L Boehm
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Apr 17, 2020·Frontiers in Behavioral Neuroscience·Trevor T Towner, Elena I Varlinskaya
Jul 22, 2019·Pharmacology, Biochemistry, and Behavior·Rabha M YounisM Imad Damaj
May 1, 2021·International Journal of Molecular Sciences·Anna K RadkeFrederic W Hopf

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