Adolescent cholesterol metabolism predicts coronary risk factors at middle age: the Cardiovascular Risk in Young Finns Study

Translational Research : the Journal of Laboratory and Clinical Medicine
Tatu A MiettinenJ S Viikari

Abstract

Atherosclerosis develops at an early age. We studied whether cholesterol metabolism in adolescence is related to coronary risk factors later during the adult years. A random population sample of 12-year-old (n=162), 15-year-old (n=158), and 18-year-old (n=148) boys who participated in the Cardiovascular Risk in Young Finns Study was studied for major coronary risk factors in 1980 and 2001. These values were related to noncholesterol sterols and their quartiles in 1980 (ie, markers of cholesterol absorption and synthesis). In 1980, serum triglycerides, body mass index (BMI), and systolic blood pressure were lower and high-density lipoprotein (HDL) cholesterol was higher in high absorbers versus low absorbers. This difference, except HDL cholesterol, was maintained after follow-up (eg, in 2001, systolic blood pressure was 123+/-1 mm Hg in low absorbers vs 119+/-1 mm Hg in high absorbers, P<0.01). Cholesterol synthesis (r = up to 0.470, P<0.001) and absorption (r = down to -0.347, P<0.001) were related to BMI at baseline and after follow-up. Significant associations were also found between cholesterol metabolism and serum triglycerides, blood pressure, and HDL cholesterol after follow-up. Cholesterol absorption was related to LDL ...Continue Reading

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Citations

Aug 31, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Costan G MagnussenOlli T Raitakari
Jul 11, 2009·Journal of Physiology and Biochemistry·T SanclementeA L García-Otín
Jun 19, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S KosolaM P Pakarinen
Apr 30, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·V D F de MelloM Uusitupa
Jan 1, 2020·International Journal of Environmental Research and Public Health·Carlos GarzaKyung-Shin Park

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