Adolescent epigenetic profiles and environmental exposures from early life through peri-adolescence.

Environmental Epigenetics
Jaclyn M GoodrichKaren E Peterson

Abstract

Epigenetic perturbations induced by environmental exposures at susceptible lifestages contribute to disease development. Even so, the influence of early life and ongoing exposures on the adolescent epigenome is rarely examined. We examined the association of exposure biomarkers for lead (Pb), bisphenol A (BPA), and nine phthalates metabolites with blood leukocyte DNA methylation at LINE-1 repetitive elements and environmentally responsive genes ( IGF2 , H19 , and HSD11B2 ) in peri-adolescents. Participants ( n  = 247) from the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) birth cohorts were followed-up once between the ages of 8 and 14 years, and concurrent exposures were measured in biospecimen collected at that time (blood Pb, urinary BPA, and phthalate metabolites). Prenatal and childhood exposures to Pb were previously approximated using maternal and child samples. BPA and phthalate metabolites were measured in third trimester maternal urine samples. Significant associations ( P  < 0.05) were observed between DNA methylation and exposure biomarkers that were gene and biomarker specific. For example, Pb was only associated with LINE-1 hypomethylation during pregnancy ( P  = 0.04), while early childhood ...Continue Reading

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Citations

Mar 8, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Luke MontroseDana C Dolinoy
Dec 24, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Ainash ChildebayevaAbigail W Bigham
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Jan 18, 2020·Environmental Health Perspectives·Felicia Fei-Lei Chung, Zdenko Herceg
Apr 16, 2019·Current Epidemiology Reports·Fu-Ying Tian, Carmen J Marsit
Mar 14, 2019·Environmental Epigenetics·Yue WuKaren E Peterson
Jul 6, 2019·Frontiers in Public Health·Alison BowmanJaclyn M Goodrich
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Mar 29, 2020·Environmental Science and Pollution Research International·Toshiaki YoshidaNaomi Sakon
Sep 23, 2020·International Journal of Environmental Research and Public Health·Luke MontroseDana C Dolinoy
Dec 26, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Yue WuJaclyn M Goodrich
Nov 14, 2020·Genome Biology and Evolution·Ainash ChildebayevaAbigail W Bigham
Feb 11, 2021·Genome Biology and Evolution·Ainash ChildebayevaAbigail W Bigham
Jul 3, 2021·Biomedicines·Lucia MiglioreAndrea Stoccoro
Jul 25, 2021·International Journal of Environmental Research and Public Health·Kyung-Shin LeeYun-Chul Hong

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Methods Mentioned

BETA
PCA
atomic absorption spectroscopy
PCR

Software Mentioned

Pyro Q - CpG Software
Sequenom EpiTYPER

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