Adolescent exposure to cannabinoids induces long-lasting changes in the response to drugs of abuse of rat midbrain dopamine neurons.

Biological Psychiatry
Marco PistisGian Luigi Gessa

Abstract

Recent studies have raised concerns about subtle long-lasting neurobiological changes that might be triggered by exposure to Cannabis derivatives, especially in a critical phase of brain maturation, such as puberty. The mesolimbic dopamine (DA) system, involved in the processing of drug-induced reward, is a locus of action of cannabinoids and endocannabinoids. Thus, we compared the effects of repeated cannabinoid administration in adolescent and adult rats on DA neuronal functions and responses to drugs of abuse. Single-unit extracellular recordings from antidromically identified mesoaccumbens DA neurons and from their target cells in the nucleus accumbens were carried out in urethane-anesthetized rats. Animals were pretreated during adolescence or adulthood, for 3 days, with the cannabinoid agonist WIN55212.2 (WIN) or vehicle and allowed a 2-week interval. In cannabinoid-administered rats, DA neurons were significantly less responsive to the stimulating action of WIN, regardless of the age of pretreatment; however, in the adolescent group, but not in the adult, long-lasting cross-tolerance developed to morphine, cocaine, and amphetamine. Our study suggests that an enduring form of neuronal adaptation occurs in DA neurons after...Continue Reading

References

Jul 1, 1975·Archives of General Psychiatry·D Kandel, R Faust
Nov 28, 1975·Science·D Kandel
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M HerkenhamK C Rice
Jan 1, 1986·The American Journal of Drug and Alcohol Abuse·L H Primavera, R Pascal
Jan 1, 1985·Psychopharmacology·A Stiglick, H Kalant
Nov 21, 1995·Brain Research. Developmental Brain Research·M H TeicherJ C Hostetter
Mar 7, 1998·European Journal of Pharmacology·G L GessaM Diana
Jul 3, 1999·Trends in Pharmacological Sciences·J ManzanaresJ A Fuentes
Sep 29, 1999·Neuroreport·F M LewekeD Piomelli
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Feb 15, 2001·Brain Research. Developmental Brain Research·G P DemyanenkoP F Maness
Mar 29, 2001·Pharmacology, Biochemistry, and Behavior·G LaviolaS Pieretti
Apr 3, 2001·European Journal of Pharmacology·M D AcetoB B Martin
Apr 9, 2001·Brain Research·F E PontieriF R Patacchioli
Aug 23, 2001·European Journal of Pharmacology·F E PontieriF R Patacchioli
Sep 29, 2001·The European Journal of Neuroscience·T RubinoD Parolaro
Apr 20, 2002·Alcoholism, Clinical and Experimental Research·Craig J Slawecki
Apr 27, 2002·Science·Rachel I Wilson, Roger A Nicoll
Jun 7, 2002·Current Opinion in Neurobiology·Anatol C Kreitzer, Wade G Regehr
Jul 9, 2002·The European Journal of Neuroscience·Bela SzaboIlka Wallmichrath
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·John W Muschamp, Stephen M Siviy

❮ Previous
Next ❯

Citations

Jul 25, 2009·Psychopharmacology·Emilio Fernandez-EspejoFernando Rodriguez de Fonseca
Jul 3, 2009·European Archives of Psychiatry and Clinical Neuroscience·Miriam Schneider
Aug 21, 2013·Neuropharmacology·Yasmin L HurdDidier Jutras-Aswad
Aug 15, 2008·Psychological Medicine·M Rutter, R Plomin
Oct 28, 2005·Nature Neuroscience·Nora Volkow, Ting-Kai Li
Jun 26, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lydie J MorelValérie Daugé
Dec 16, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Salvatore LeccaMarco Pistis
Mar 22, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Aine T BehanDavid R Cotter
Dec 14, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Miriam Schneider, Michael Koch
Jun 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alejandro Higuera-MatasEmilio Ambrosio
Jan 4, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Tiziana RubinoDaniela Parolaro
May 17, 2008·Addiction Biology·Patricia RobledoRafael Maldonado
Aug 5, 2009·Addiction Biology·Krista Lisdahl MedinaSusan F Tapert
Oct 1, 2006·Acta Neuropsychiatrica·Murat YücelChristos Pantelis
Sep 19, 2012·Developmental Neuroscience·John C ChurchwellDeborah A Yurgelun-Todd
Jul 1, 2006·Critical Reviews in Neurobiology·Sari Izenwasser
Jan 30, 2014·Annual Review of Clinical Psychology·Ruud van Winkel, Rebecca Kuepper
Jun 5, 2014·The New England Journal of Medicine·Nora D VolkowSusan R B Weiss
Feb 12, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rassil Ghazzaoui, Anissa Abi-Dargham
Nov 5, 2010·Psychopharmacology·Johannes G RamaekersGerhold Kauert
Sep 16, 2014·Drug and Alcohol Dependence·Marisol S CastanetoMarilyn A Huestis
Nov 26, 2015·Developmental Cognitive Neuroscience·Mary P BeckerM Luciana
Dec 3, 2014·Pharmacology & Therapeutics·Dan I LubmanMurat Yücel
Feb 14, 2015·Addictive Behaviors·Les B Whitbeck, Brian E Armenta
Feb 1, 2012·Biological Psychiatry·Nina B L UrbanAnissa Abi-Dargham
Jan 16, 2016·The Journal of the American Dental Association·Sarah Essek GraftonAlexandre R Vieira
Jul 27, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alejandro Higuera-MatasEmilio Ambrosio
Apr 24, 2010·Psychiatry Research·Krista Lisdahl MedinaSusan F Tapert
Nov 4, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marta Rodríguez-AriasJosé Miñarro
Mar 25, 2008·Molecular and Cellular Endocrinology·T Rubino, D Parolaro
Apr 17, 2008·British Journal of Pharmacology·B Boutrel
Jun 1, 2007·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Krista Lisdahl MedinaSusan F Tapert
Feb 24, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Michael RutterAvshalom Caspi
Sep 22, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maria SchermaPaola Fadda
Aug 29, 2013·The Journal of Comparative Neurology·Leora YetnikoffDaniel S Zahm
Oct 11, 2013·British Journal of Pharmacology·J H P van WelJ G Ramaekers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

© 2022 Meta ULC. All rights reserved