Adolescent Hippocampal and Prefrontal Brain Activation During Performance of the Virtual Morris Water Task

Frontiers in Human Neuroscience
Jennifer T SneiderMarisa M Silveri

Abstract

The frontal cortex undergoes substantial structural and functional changes during adolescence and significant developmental changes also occur in the hippocampus. Both of these regions are notably vulnerable to alcohol and other substance use, which is typically initiated during adolescence. Identifying measures of brain function during adolescence, particularly before initiation of drug or alcohol use, is critical to understanding how such behaviors may affect brain development, especially in these vulnerable brain regions. While there is a substantial developmental literature on adolescent working memory, less is known about spatial memory. Thus, a virtual Morris water task (vMWT) was applied to probe function of the adolescent hippocampus. Multiband blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) data were acquired at 3T during task performance. Participants included 32 healthy, alcohol- and drug-naïve adolescents, 13-14 years old, examined at baseline of a 3-year longitudinal MRI study. Significantly greater BOLD activation was observed in the hippocampus and surrounding areas, and in prefrontal regions involved in executive function, during retrieval relative to motor performance. In contra...Continue Reading

References

May 1, 1984·Journal of Neuroscience Methods·R Morris
Jul 1, 1993·Behavioral and Neural Biology·L E Jarrard
May 14, 1999·Current Opinion in Neurobiology·E A MaguireJ O'Keefe
Mar 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·E A MaguireC D Frith
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Feb 21, 2002·Behavioural Brain Research·Robert S AsturRobert J Sutherland
Jun 5, 2003·The American Journal of Psychiatry·R Andrew ChambersMarc N Potenza
Jan 26, 2005·Trends in Cognitive Sciences·Tomás Paus
Jul 17, 2007·Behavioural Brain Research·Paul NewhouseRobert S Astur
Dec 7, 2007·Behavioural Brain Research·Seth L Shipman, Robert S Astur
Jan 6, 2009·Behavioural Processes·Derek A HamiltonSteven P Verney
Jan 24, 2009·NeuroImage·Adrian R GrovesMark W Woolrich
Mar 26, 2009·Learning & Memory·Joseph M Andreano, Larry Cahill
Mar 25, 2010·The Journal of Clinical Psychiatry·David V SheehanBerney Wilkinson
Oct 19, 2010·Neuropsychology Review·Sunita Bava, Susan F Tapert
Nov 26, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·B J Casey, Rebecca M Jones
Dec 22, 2011·Perceptual and Motor Skills·Jennifer Tropp SneiderDeborah A Yurgelun-Todd
May 2, 2012·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mohamed L Seghier
Oct 12, 2012·Social Cognitive and Affective Neuroscience·Kathryn L MillsSarah-Jayne Blakemore
Aug 21, 2013·Journal of Addiction·Jennifer Tropp SneiderDeborah A Yurgelun-Todd
Sep 10, 2013·Brain Research·Lindsay M SquegliaSusan F Tapert
Jul 20, 2014·Neurobiology of Learning and Memory·Louisa Dahmani, Véronique D Bohbot
Dec 3, 2014·Behavioural Processes·Jennifer T SneiderMarisa M Silveri
Mar 17, 2015·NeuroImage·Raimon H R PruimChristian F Beckmann
Oct 23, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sebastian GuderianFaraneh Vargha-Khadem
Apr 6, 2016·Journal of Interpersonal Violence·Kendon J ConradMadelyn Iris
Jul 1, 2016·Psychonomic Bulletin & Review·Daniel VoyerJean Saint-Aubin
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Marisa M SilveriJennifer T Sneider
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Sarah D LichensteinErika E Forbes
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Vishnu P MurtyBeatriz Luna
Aug 30, 2017·Behavioural Brain Research·Dominique PiberChristian Otte

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Citations

Apr 23, 2019·Journal of Child and Adolescent Psychopharmacology·Lindsay M SquegliaKevin M Gray
Jul 28, 2020·Neuroscience·Wenfei ChenBin Wang
Mar 20, 2021·The European Journal of Neuroscience·Alexandre DelauxAngelo Arleo

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