Adolescent isolation rearing produces a prepulse inhibition deficit correlated with expression of the NMDA GluN1 subunit in the nucleus accumbens

Brain Structure & Function
M L Fitzgerald, V M Pickel

Abstract

Adolescence is a transition period during which social interaction is necessary for normal brain and behavior development. Severely abnormal social interactions during adolescence can increase the incidence of lifelong psychiatric disease. Decreased prepulse inhibition (PPI) is a quantifiable hallmark of some psychiatric illnesses in humans and can be elicited in rodents by isolation rearing throughout the adolescent transition period. PPI is a measure of sensorimotor gating in which the nucleus accumbens (Acb) is crucially involved. The Acb is comprised of core and shell subregions, which receive convergent dopaminergic and glutamatergic inputs. To gain insight into the neurobiological correlates of adolescent adversity, we conducted electron microscopic immunolabeling of dopamine D1 receptors (D1Rs) and the GluN1 subunit of glutamate NMDA receptors in the Acb of isolation-reared (IR) adult male rats. In all animals, GluN1 was primarily located in dendritic profiles, many of which also contained D1Rs. GluN1 was also observed in perisynaptic glia and axon terminals. In IR rats compared with group-reared controls, GluN1 density was selectively decreased in D1R-containing dendrites of the Acb core. Across all animals, dendritic G...Continue Reading

References

Feb 1, 1994·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L S WilkinsonT W Robbins
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A I LeveyB J Ciliax
May 30, 1998·Journal of Neuroscience Methods·T SaitoT Nemoto
Jul 23, 1999·Annals of the New York Academy of Sciences·H J GroenewegenP Voorn
Sep 25, 1999·Physiology & Behavior·V P Bakshi, M A Geyer
May 19, 2000·Neuroscience and Biobehavioral Reviews·L P Spear
Aug 20, 2003·Neuron·Robert C FroemkeYang Dan
May 23, 2006·Current Opinion in Neurobiology·Ian Duguid, Per Jesper Sjöström
Jan 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Marcello D'AscenzoPhilip G Haydon
Oct 17, 2008·Nature·Melissa B Ramocki, Huda Y Zoghbi
Jul 25, 2009·Brain and Cognition·Catherine SebastianSarah-Jayne Blakemore
Nov 26, 2010·Journal of the American Academy of Child and Adolescent Psychiatry·B J Casey, Rebecca M Jones
Sep 14, 2011·Methods in Molecular Biology·Teresa A MilnerJoseph P Pierce
Apr 2, 2014·The American Journal of Psychiatry·Thomas R Insel
Aug 15, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lydie MorelYongjie Yang
Feb 28, 2015·Stereotactic and Functional Neurosurgery·Sanjay Salgado, Michael G Kaplitt
Aug 11, 2015·Neuroscience and Biobehavioral Reviews·Gilbert J Kirouac
May 31, 2016·Psychophysiology·Suzanne L PinelesScott P Orr

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