Adolescent Maturation of Dopamine D1 and D2 Receptor Function and Interactions in Rodents

PloS One
Jennifer B Dwyer, Frances M Leslie

Abstract

Adolescence is a developmental period characterized by heightened vulnerability to illicit drug use and the onset of neuropsychiatric disorders. These clinical phenomena likely share common neurobiological substrates, as mesocorticolimbic dopamine systems actively mature during this period. Whereas prior studies have examined age-dependent changes in dopamine receptor binding, there have been fewer functional analyses. The aim of the present study was therefore to determine whether the functional consequences of D1 and D2-like activation are age-dependent. Adolescent and adult rats were given direct D1 and D2 agonists, alone and in combination. Locomotor and stereotypic behaviors were measured, and brains were collected for analysis of mRNA expression for the immediate early genes (IEGs), cfos and arc. Adolescents showed enhanced D2-like receptor control of locomotor and repetitive behaviors, which transitioned to dominant D1-like mechanisms in adulthood. When low doses of agonists were co-administered, adults showed supra-additive behavioral responses to D1/D2 combinations, whereas adolescents did not, which may suggest age differences in D1/D2 synergy. D1/D2-stimulated IEG expression was particularly prominent in the bed nucl...Continue Reading

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Citations

Jan 10, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Iwona Majcher-MaślankaAgnieszka Chocyk
Nov 30, 2018·Journal of Psychopharmacology·Tracey A LarsonRyan K Bachtell
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Nov 20, 2019·Translational Psychiatry·Jennifer B DwyerFrances M Leslie
Apr 22, 2020·Proceedings of the National Academy of Sciences of the United States of America·Maria SchermaPhilippe A Melas
Mar 4, 2021·The American Journal of Psychiatry·Jennifer B DwyerMichael H Bloch
Oct 19, 2017·Hormones and Behavior·Madeleine SalvatoreDebra A Bangasser
Apr 27, 2021·Expert Opinion on Drug Metabolism & Toxicology·Jacob T BrownJeffrey R Bishop
Mar 5, 2021·Behavioural Pharmacology·Sarah J Cross, Frances M Leslie

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

Netdraw
UCINET
Matlab
Coordinated Gene Expression ( CGE ) Analysis

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