Adolescent maturation of inhibitory inputs onto cingulate cortex neurons is cell-type specific and TrkB dependent

Frontiers in Neural Circuits
Angela VandenbergLinda Wilbrecht

Abstract

The maturation of inhibitory circuits during adolescence may be tied to the onset of mental health disorders such as schizophrenia. Neurotrophin signaling likely plays a critical role in supporting inhibitory circuit development and is also implicated in psychiatric disease. Within the neocortex, subcircuits may mature at different times and show differential sensitivity to neurotrophin signaling. We measured miniature inhibitory and excitatory postsynaptic currents (mIPSCs and mEPSCs) in Layer 5 cell-types in the mouse anterior cingulate (Cg) across the periadolescent period. We differentiated cell-types mainly by Thy1 YFP transgene expression and also retrobead injection labeling in the contralateral Cg and ipsilateral pons. We found that YFP- neurons and commissural projecting neurons had lower frequency of mIPSCs than neighboring YFP+ neurons or pons projecting neurons in juvenile mice (P21-25). YFP- neurons and to a lesser extent commissural projecting neurons also showed a significant increase in mIPSC amplitude during the periadolescent period (P21-25 vs. P40-50), which was not seen in YFP+ neurons or pons projecting neurons. Systemic disruption of tyrosine kinase receptor B (TrkB) signaling during P23-50 in TrkBF616A mi...Continue Reading

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Citations

Jan 25, 2019·Cold Spring Harbor Symposia on Quantitative Biology·Kristen DelevichLinda Wilbrecht
Jan 19, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Amir ShojaeiNafiseh Atapour
Feb 14, 2021·Neuroscience and Biobehavioral Reviews·Nicole C FerraraJ Amiel Rosenkranz
May 15, 2021·Seminars in Cell & Developmental Biology·Kristen DelevichLinda Wilbrecht

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Methods Mentioned

BETA
transgenic

Software Mentioned

Matlab
MiniAnalysis
Graphpad Prism
PClamp

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