Adolescent nicotine exposure disrupts context conditioning in adulthood in rats.

Pharmacology, Biochemistry, and Behavior
Andrea M SpaethJoshua A Burk

Abstract

Despite the prevalence of smoking among adolescents, few studies have assessed the effects of adolescent nicotine exposure on learning in adulthood. In particular, it remains unclear whether adolescent nicotine exposure has effects on hippocampus-dependent learning that persist into adulthood. The present experiment examined whether there were effects of adolescent nicotine exposure on context conditioning, a form of learning dependent on the integrity of the hippocampus, when tested during adulthood. Rats were exposed to nicotine during adolescence (postnatal days [PD] 28-42) via osmotic minipump (0, 3.0 or 6.0mg/kg/day). Context conditioning occurred in early adulthood (PD 65-70). Animals were exposed to an experimental context and were given 10 unsignaled footshocks or no shock. Additional groups were included to test the effects of adolescent nicotine on delay conditioning, a form of learning that is not dependent upon the hippocampus. Conditioning was assessed using a lick suppression paradigm. For animals in the context conditioning groups, adolescent nicotine resulted in significantly less suppression of drinking in the presence of context cues compared with vehicle-pretreated animals. For animals in the delay conditioni...Continue Reading

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Citations

May 16, 2013·Neurotoxicology and Teratology·Laura R G PickensStephen B Fountain
May 20, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Sarah N CampionGregg D Cappon
Apr 14, 2016·Neuroscience and Biobehavioral Reviews·Erica Holliday, Thomas J Gould
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Apr 24, 2012·Neurobiology of Learning and Memory·George S PortugalThomas J Gould
Sep 11, 2016·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Erica D Holliday, Thomas J Gould
Aug 18, 2018·Learning & Memory·Sean M Mooney-Leber, Thomas J Gould
Aug 18, 2021·The European Journal of Neuroscience·Sean M Mooney-LeberHelen M Kamens

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