Adolescent Rats Self-Administer Less Nicotine Than Adults at Low Doses

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco
Rachel L SchassburgerAlan F Sved

Abstract

Although nearly 90% of current smokers initiated tobacco use during adolescence, little is known about reinforcement by nicotine in adolescents. Researchers are currently investigating whether a potential public health policy setting a tobacco product standard with very low nicotine levels would improve public health, and it is essential to understand whether data generated in adults translates to adolescents, particularly as it relates to the threshold dose of nicotine required to support smoking. The present study compared self-administration of low doses of nicotine between adolescent and adult rats. Adolescent (postnatal day [P] 30) and adult (P90) male and female rats were allowed to nosepoke to receive intravenous infusions of nicotine (3-100 μg/kg/infusion) during 16 daily 1-hour sessions. At 10 μg/kg/infusion nicotine, adolescent rats earned significantly fewer infusions than adults. When responding for 30 μg/kg/infusion nicotine, rats of both ages earned a similar number of infusions; however, there were subtle differences in the distribution of infusions across the 1-hour session. No sex differences were apparent in either age group at any dose. These results demonstrate that adolescent rats are less sensitive than ad...Continue Reading

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Citations

Dec 24, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Micah L Berman, Allison M Glasser
Dec 24, 2019·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Suzanne M ColbyJennifer W Tidey
Nov 20, 2018·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Song XueAdriaan W Bruijnzeel
Sep 28, 2016·Tobacco Control·Eric C DonnyChris Bullen
Apr 6, 2017·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Tracy T SmithAlan F Sved
May 14, 2021·Psychopharmacology·Maggie M SweitzerF Joseph McClernon
Mar 24, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Rachel N CassidyDorothy Hatsukami
Jul 1, 2021·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Dorothy K HatsukamiGeoffrey Ferris Wayne

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