Adolescent THC exposure in female rats leads to cognitive deficits through a mechanism involving chromatin modifications in the prefrontal cortex.

Journal of Psychiatry & Neuroscience : JPN
Pamela PriniT Rubino

Abstract

Increasing cannabis consumption among adolescents, studies that link its early use with mental illnesses, and the political debate on cannabis legalization together call for an urgent need to study molecular underpinnings of adolescent brain vulnerability. The emerging role of epigenetic mechanisms in psychiatric diseases led us to hypothesize that epigenetic alterations could play a role in causes and subsequent development of the depressive/psychotic-like phenotype induced by adolescent, but not adult, Δ9-tetrahydrocannabinol (THC) exposure in female rats. We performed a time-course analysis of histone modifications, chromatin remodelling enzymes and gene expression in the prefrontal cortex of female rats after adolescent and adult THC exposure. We also administered a specific epigenetic drug (chaetocin) with THC to investigate its impact on THC-induced behavioural alterations. Adolescent THC exposure induced alterations of selective histone modifications (mainly H3K9me3), impacting the expression of genes closely associated with synaptic plasticity. Changes in both histone modifications and gene expression were more widespread and intense after adolescent treatment, suggesting specific adolescent susceptibility. Adolescent T...Continue Reading

Citations

Sep 3, 2020·International Journal of Molecular Sciences·Francesco RusconiElena Battaglioli
Apr 25, 2020·EMBO Molecular Medicine·Coralie BerthouxCarine Bécamel
Jun 27, 2020·Brain Sciences·Anna GrzywaczBlazej Rubiś
Feb 26, 2021·Neural Plasticity·Huixia GengLai Wang
Feb 13, 2020·International Journal of Molecular Sciences·Rosaria MeccarielloRiccardo Pierantoni
Sep 15, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christina M RuizStephen V Mahler
Apr 30, 2020·International Journal of Molecular Sciences·Francesco RusconiMarco Venturin
Nov 27, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Zineb Ibn Lahmar AndaloussiOualid Abboussi
Aug 18, 2018·Learning & Memory·Sean M Mooney-Leber, Thomas J Gould
Dec 22, 2019·International Journal of Molecular Sciences·Marco BarchiPaola Grimaldi
Aug 29, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Erica Zamberletti, Tiziana Rubino
Apr 17, 2020·Bulletin de l'Académie nationale de médecine·J Costentin

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