Adolescents and HIV vaccine trials: what are the clinical trial site issues?

Journal of the International Association of Physicians in AIDS Care : JIAPAC
Linda-Gail BekkerGlenda Gray

Abstract

Adolescents worldwide are at high risk for HIV, which makes them essential candidates for HIV vaccine trials. However, enrollment of adolescents into such trials has implications for trial sites. Adolescents are considered vulnerable subjects and require proxy consent in addition to their assent, which brings issues of confidentiality and access into play. HIV vaccine trial sites often do not have experience recruiting and retaining adolescents, and creating youth-friendly environments that are comfortable for guardians. This includes development of education materials that target both youth and their parents. Because these trials are of minimal individual benefit, sites will likely need to provide service in the form of health care and supportive structures to adolescents. Finally, a number of trial design options exist, and researchers will need to balance the risks and benefits of each, as for all issues surrounding the involvement of adolescents in HIV vaccine trials.

References

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Nov 19, 2002·Social Science & Medicine·Liberty EatonLeif E Aarø
Feb 28, 2003·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Paulette D StanfordUNKNOWN Reaching for Excellence in Adolescent Care and Health Project
May 29, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cori A McClurePeter F Wright

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Citations

Nov 26, 2009·SAHARA J : Journal of Social Aspects of HIV/AIDS Research Alliance·Kyriaki MystakidouEfi Parpa
Jan 1, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Linda-Gail BekkerBill Kapogiannis
Jul 9, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Thomas W ValenteEva Operskalski
Jun 21, 2008·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Keren MiddelkoopLinda-Gail Bekker
Oct 31, 2015·Psychology, Health & Medicine·Shayesta Dhalla
Jul 1, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jonathan M EllenKevin Fisher

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