Adolescents at high risk of obesity show greater striatal response to increased sugar content in milkshakes

The American Journal of Clinical Nutrition
Grace E ShearrerKyle S Burger

Abstract

Children of overweight or obese parents are at a high risk of developing obesity. This study sought to examine the underlying neural factors related to parental obesity risk and the relative impact of sugar and fat when consuming a palatable food, as well as the impact of obesity risk status on brain response to appetizing food images. With the use of functional MRI, the responses of 108 healthy-weight adolescents [mean ± SD body mass index (kg/m2): 20.9 ± 1.9; n = 53 who were at high risk by virtue of parental obesity status, n = 55 who were low risk] to food stimuli were examined. Stimuli included 4 milkshakes, which systematically varied in sugar and fat content, a calorie-free tasteless solution, and images of appetizing foods and glasses of water. High-risk compared with low-risk adolescents showed greater blood oxygen-dependent response to milkshakes (all variants collapsed) compared with the tasteless solution in the primary gustatory and oral somatosensory cortices (P-family-wise error rate < 0.05), replicating a previous report. Notably, high-risk adolescents showed greater caudate, gustatory, and oral somatosensory responses to the high-sugar milkshake than to the tasteless solution; however, no effect of risk status ...Continue Reading

Associated Clinical Trials

References

Jan 6, 2017·Nature Reviews. Neuroscience·Russell A PoldrackTal Yarkoni

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Citations

Apr 5, 2019·Current Nutrition Reports·Pawel K OlszewskiAllen S Levine
Jul 29, 2020·Current Nutrition Reports·Oh-Ryeong HaAmanda S Bruce
Apr 17, 2021·Neuropharmacology·Katherine M SerafineEric P Zorrilla
Aug 31, 2021·Frontiers in Psychology·Oh-Ryeong HaSeung-Lark Lim
Oct 1, 2021·Current Obesity Reports·Eric Stice, Sonja Yokum
Dec 23, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Maren LaughlinLuke E Stoeckel

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