Adopting genetics: motivations and outcomes of personal genomic testing in adult adoptees

Genetics in Medicine : Official Journal of the American College of Medical Genetics
Natalie M BaptistaRobert C Green

Abstract

American adult adoptees may possess limited information about their biological families and turn to direct-to-consumer personal genomic testing (PGT) for genealogical and medical information. We investigated the motivations and outcomes of adoptees undergoing PGT using data from the Impact of Personal Genomics (PGen) Study. The PGen Study surveyed new 23andMe and Pathway Genomics customers before and 6 months after receiving PGT results. Exploratory analyses compared adoptees' and nonadoptees' PGT attitudes, expectations, and experiences. We evaluated the association of adoption status with motivations for testing and postdisclosure actions using logistic regression models. Of 1,607 participants, 80 (5%) were adopted. As compared with nonadoptees, adoptees were more likely to cite limited knowledge of family health history (OR = 10.1; 95% CI = 5.7-19.5) and the opportunity to learn genetic disease risks (OR = 2.7; 95% CI = 1.6-4.8) as strong motivations for PGT. Of 922 participants who completed 6-month follow-up, there was no significant association between adoption status and PGT-motivated health-care utilization or health-behavior change. PGT allows adoptees to gain otherwise inaccessible information about their genetic dise...Continue Reading

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Citations

Oct 6, 2016·Journal of Genetic Counseling·Brianne E Kirkpatrick, Misha D Rashkin
Jan 1, 2018·HEC Forum : an Interdisciplinary Journal on Hospitals' Ethical and Legal Issues·Thomas May, Harold Grotevant
Feb 2, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kurt D ChristensenKatrina A B Goddard
Dec 5, 2017·European Journal of Human Genetics : EJHG·J C HarperUNKNOWN on behalf of the European Society of Human Reproduction and Embryology and European Society of Human Genetics
Dec 13, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stacy W GrayRobert C Green
May 4, 2017·BMC Medical Genomics·Daiva Elena NielsenUNKNOWN PGen Study Group
Dec 3, 2016·The American Journal of Bioethics : AJOB·Thomas MayHarold D Grotevant
Dec 4, 2017·Human Reproduction Open·J C HarperUNKNOWN European Society of Human Reproduction and Embryology and European Society of Human Genetics
Jan 15, 2021·Journal of Medical Genetics·Jessica EdgarSara Spencer
Jul 28, 2021·Molecular Genetics & Genomic Medicine·Meagan CochranDavid Bick

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Software Mentioned

Pathway Genomics
R Foundation for Statistical Computing
R

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