Adoptive Cell Therapy in Breast Cancer: A Current Perspective of Next-Generation Medicine

Frontiers in Oncology
Jesús Fuentes-AntrásAlberto Ocaña

Abstract

Immunotherapy has become a cornerstone in the treatment of cancer and changed the way clinicians and researchers approach tumor vulnerabilities. Durable responses are commonly observed with immune checkpoint inhibitors in highly immunogenic tumors, while the infusion of T cells genetically engineered to express chimeric antigen receptors (CARs) has shown impressive efficacy in certain types of blood cancer. Nevertheless, harnessing our own immunity has not proved successful for most breast cancer patients. In the era of genomic medicine, cellular immunotherapies may provide a more personalized and dynamic tool against tumors displaying heterogeneous mutational landscapes and antigenic pools. This approach encompasses multiple strategies including the adoptive transfer of tumor-infiltrating lymphocytes, dendritic cells, natural killer cells, and engineered immune components such as CAR constructs and engineered T cell receptors. Although far from permeating the clinical setting, technical advances have been overwhelming in recent years, with continuous improvement in traditional challenges such as toxicity, adoptive cell persistence, and intratumoral trafficking. Also, there is an avid search for neoantigens that can be targeted...Continue Reading

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Citations

Mar 27, 2021·World Journal of Clinical Oncology·David O'ReillyCatherine M Kelly
Jun 22, 2021·International Immunopharmacology·Khadijeh BarzamanLeila Farahmand
Jul 9, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Catarina Nascimento, Fernando Ferreira

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Methods Mentioned

BETA
biopsies
xenograft

Clinical Trials Mentioned

NCT04111510
NCT01462903
NCT01174121
NCT00301730
NCT04102436
NCT03970382
NCT03412877
NCT03159585
NCT02457650
NCT02111850

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