Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes in Advanced Melanoma Patients

Journal of Immunology Research
Mélanie Saint-JeanBrigitte Dréno

Abstract

Immunotherapy for melanoma includes adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TILs). This monocenter retrospective study was undertaken to evaluate the efficacy and safety of this treatment of patients with advanced melanoma. All advanced melanoma patients treated with TILs using the same TIL expansion methodology and same treatment interleukin-2 (IL-2) regimen between 2009 and 2012 were included. After sterile intralesional excision of a cutaneous or subcutaneous metastasis, TILs were produced according to a previously described method and then infused into the patient who also received a complementary subcutaneous IL-2 regimen. Nine women and 1 man were treated for unresectable stage IIIC (n = 4) or IV (n = 6) melanoma. All but 1 patient with unresectable stage III melanoma (1st line) had received at least 2 previous treatments, including anti-CTLA-4 antibody for 4. The number of TILs infused ranged from 0.23 × 109 to 22.9 × 109. Regarding safety, no serious adverse effect was reported. Therapeutic responses included a complete remission, a partial remission, 2 stabilizations, and 6 progressions. Among these 4 patients with clinical benefit, 1 is still alive with 9 years of follow-up and 1 died fro...Continue Reading

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Citations

Oct 20, 2018·Future Oncology·Nicole A Carreau, Anna C Pavlick
Sep 27, 2019·Frontiers in Immunology·Kalliopi IoannidouDaniel E Speiser
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Jul 28, 2020·Life Sciences·Karanpreet BhatiaAsmita Das
Aug 28, 2021·Biomedicines·Daniel-Clement Osei-BordomNiki Christou

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Methods Mentioned

BETA
biopsy
Assay
flow cytometry
Fluorescence-activated cell sorting

Clinical Trials Mentioned

NCT00324155
NCT00338130

Software Mentioned

BDFACS Diva
FACSCanto
R

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