Adoptive immunotherapy for cancer: building on success.

Nature Reviews. Immunology
Luca GattinoniNicholas P Restifo

Abstract

Adoptive cell transfer after host preconditioning by lymphodepletion represents an important advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment enables tumour-reactive T cells to destroy large burdens of metastatic tumour and how the state of differentiation of the adoptively transferred T cells can affect the outcome of treatment. We also discuss how the translation of these new findings might further improve the efficacy of adoptive cell transfer through the use of vaccines, haematopoietic-stem-cell transplantation, modified preconditioning regimens, and alternative methods for the generation and selection of the T cells to be transferred.

Associated Clinical Trials

Oct 11, 2010·Steven Rosenberg, M.D., Steven Rosenberg, M.D.

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