Adoptive immunotherapy for relapsed leukemia following allogeneic bone marrow transplantation

Leukemia & Lymphoma
D L Porter, J H Antin

Abstract

Donor mononuclear cell (MNC) infusions provide a very potent and effective anti-leukemic therapy. For patient's with CML who relapse after allogeneic BMT, the administration of donor MNC can result in a direct GVL effect and re-establish sustained remissions, even when assessed by very sensitive PCR-based techniques. The GVL reaction appears to be most prominent in patients with chronic phase CML. It is less apparent for patients with more advanced stages of CML or for patients with relapsed acute leukemia and myelodysplasia, although only small numbers of these patients have been treated. While the majority of patients tolerate this therapy very well, treatment related morbidity and mortality is still quite significant, and efforts to limit the severity of GVHD, and to recognize and treat marrow aplasia early may be useful. Longer follow-up of patients who have achieved complete remission will be required to determine if this therapy will have an impact on long term disease free survival, but at the current time, it would seem to be a very acceptable alternative to a second BMT.

References

May 10, 1979·The New England Journal of Medicine·P L WeidenR Storb
Feb 1, 1990·The New England Journal of Medicine·K E AndersonR B Stead
Mar 30, 1989·The New England Journal of Medicine·K M SullivanJ Hansen
Jul 7, 1984·Lancet·R P Gale, R E Champlin
Jan 13, 1994·The New England Journal of Medicine·D L PorterJ H Antin
Feb 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J P RadichJ A Hansen
Mar 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B M BärT De Witte
Jul 1, 1957·British Journal of Haematology·D W BARNES, J F LOUTIT

❮ Previous
Next ❯

Citations

Jan 20, 1999·The British Journal of Dermatology·M Jones-CaballeroA García-Díez
Jul 20, 2010·Immunotherapy·Joshua Brody, Ronald Levy
Nov 15, 2011·Journal of Strength and Conditioning Research·Ana L Dias QuiterioLuís B Sardinha
Sep 26, 2006·Best Practice & Research. Clinical Haematology·David L Porter, Joseph H Antin
Jul 16, 1999·Pediatric Pulmonology·H LeneveuG Dutau
Aug 1, 1997·Disease-a-month : DM·P Jacobs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.