Adoptive T-cell therapy improves treatment of canine non-Hodgkin lymphoma post chemotherapy.

Scientific Reports
Colleen M O'ConnorLaurence J Cooper

Abstract

Clinical observations reveal that an augmented pace of T-cell recovery after chemotherapy correlates with improved tumor-free survival, suggesting the add-back of T cells after chemotherapy may improve outcomes. To evaluate adoptive immunotherapy treatment for B-lineage non-Hodgkin lymphoma (NHL), we expanded T cells from client-owned canines diagnosed with NHL on artificial antigen presenting cells (aAPC) in the presence of human interleukin (IL)-2 and IL-21. Graded doses of autologous T cells were infused after CHOP chemotherapy and persisted for 49 days, homed to tumor, and significantly improved survival. Serum thymidine kinase changes predicted T-cell engraftment, while anti-tumor effects correlated with neutrophil-to-lymphocyte ratios and granzyme B expression in manufactured T cells. Therefore, chemotherapy can be used to modulate infused T-cell responses to enhance anti-tumor effects. The companion canine model has translational implications for human immunotherapy which can be readily exploited since clinical-grade canine and human T cells are propagated using identical approaches.

References

Jan 1, 1996·Annual Review of Immunology·D J LenschowJ A Bluestone
Mar 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Angelo AquinoEnzo Bonmassar
Nov 18, 2004·Immunological Reviews·Devangi S MehtaMichael J Grusby
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yongqing LiCassian Yee
Dec 24, 2005·The New England Journal of Medicine·Franck PagèsJérôme Galon
Jan 31, 2006·Nature Biotechnology·Bonnee RubinfeldPaul Polakis
Apr 18, 2006·Current Opinion in Immunology·Christian S HinrichsNicholas P Restifo
Apr 20, 2006·Nature Reviews. Immunology·Luca GattinoniNicholas P Restifo
Aug 8, 2006·British Journal of Haematology·Mustaqeem SiddiquiLuis F Porrata
Oct 10, 2006·Veterinary Immunology and Immunopathology·R J MilnerJ Farese
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan M CoquetDale I Godfrey
Mar 22, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Megan M SuhoskiCarl H June
Jun 26, 2007·Experimental Hematology·Tontanai NumbenjaponLaurence J N Cooper
Oct 24, 2007·The Veterinary Clinics of North America. Small Animal Practice·Melissa C Paoloni, Chand Khanna
Jan 19, 2008·Nature Reviews. Cancer·Melissa Paoloni, Chand Khanna
Feb 19, 2008·Nature Biotechnology·Gary K GeissKrassen Dimitrov
Apr 17, 2008·Cancer Research·Harjeet SinghLaurence J N Cooper
May 20, 2008·Cancer Immunology, Immunotherapy : CII·Lee MachadoSteven P Lee
Jun 11, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Luis F PorrataSvetomir N Markovic
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Khalid I Al-ShibliLill-Tove Busund
Jun 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Galina V ShurinMichael R Shurin
Nov 27, 2009·Cancer Immunology, Immunotherapy : CII·Miki TonguMamoru Harada
Jun 10, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniela PeruzziLuigi Aurisicchio
Sep 16, 2010·American Journal of Hematology·Luis F PorrataSvetomir N Markovic
Oct 20, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven C H KaoStephen J Clarke

❮ Previous
Next ❯

Citations

Jan 9, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Drew C DenigerLaurence J N Cooper
Feb 5, 2013·Journal of Immunotherapy·Sourindra N MaitiLaurence J N Cooper
Feb 4, 2014·Current Hematologic Malignancy Reports·Bipulendu JenaLaurence J N Cooper
Sep 5, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jacqueline Corrigan-CurayDonald B Kohn
Apr 12, 2016·Veterinary Sciences·Katie L Anderson, Jaime F Modiano
Mar 10, 2016·The Veterinary Quarterly·M Zandvliet
Feb 24, 2015·The Journal of Small Animal Practice·D R KillickB Catchpole
Jan 8, 2015·Frontiers in Immunology·Drew C DenigerLaurence J N Cooper
Dec 31, 2014·Cancer Immunology, Immunotherapy : CII·Federica RiccardoFederica Cavallo
Jul 13, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·M Kazim PanjwaniNicola J Mason
Oct 1, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Melinda Mata, Stephen Gottschalk
Nov 27, 2018·ILAR Journal·Nana H OvergaardGregers Jungersen
Jun 18, 2014·ILAR Journal·Colleen M O'Connor, Heather Wilson-Robles
Dec 6, 2019·Frontiers in Oncology·Douglas H Thamm
May 11, 2016·Journal of Immunotherapy·Hillary G CarusoLaurence J N Cooper
Feb 21, 2018·Frontiers in Immunology·Hans Klingemann
Oct 12, 2018·Acta Veterinaria Scandinavica·Joanna Katarzyna BujakKinga Majchrzak
Jul 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Pappanaicken R KumaresanLaurence J N Cooper
Feb 15, 2019·Veterinary Sciences·Ramón M Almela, Agustina Ansón
Dec 20, 2018·Veterinary Sciences·Selamawit Addissie, Hans Klingemann
Aug 6, 2018·Oncoimmunology·Hillary G CarusoLaurence J N Cooper
Oct 6, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Abraham J MatarRaimon Duran-Struuck
Mar 9, 2021·Frontiers in Immunology·Iwona Monika SzopaKinga Majchrzak-Kuligowska
Mar 12, 2021·Advanced Drug Delivery Reviews·Lisa A Mestrinho, Ricardo R Santos
Jun 26, 2021·Veterinary and Comparative Oncology·Samuel A Brill, Douglas H Thamm
Sep 14, 2021·Frontiers in Veterinary Science·Joana N R DiasFrederico Aires-da-Silva

❮ Previous
Next ❯

Methods Mentioned

BETA
density-gradient centrifugation
PCR
FCS
Assay

Clinical Trials Mentioned

NCT00968760

Software Mentioned

Prism
GraphPad
nCounter analysis system
nCounter Assay
Cell Quest
FCS Express

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.