Adoptive transfer of all-trans-retinal-induced regulatory T cells ameliorates experimental autoimmune arthritis in an interferon-gamma knockout model

Autoimmunity
Eun-Joo JeonSeok-Goo Cho

Abstract

Maintaining an appropriate balance between subsets of CD4(+) helper T cells and T regulatory cells (Tregs) is a critical process in immune homeostasis and a protective mechanism against autoimmunity and inflammation. To identify the role of vitamin A-related compounds, we investigated the regulation of interleukin (IL)-17-producing helper T cells (Th17 cells) and Tregs treated with all-trans-retinal (retinal). CD4(+)T cells or total cells from the spleens of C57BL/6 mice were stimulated under Treg-polarizing (anti-CD3/CD28 and TGF-β) or Th17-polarizing (anti-CD3/CD28, TGF-β, and IL-6) conditions in the presence or absence of retinal. To analyze their suppressive abilities, retinal-induced Tregs or TGF-β-induced Tregs were co-cultured with responder T cells. Collagen-induced arthritis (CIA) was established in interferon (IFN)-γ knockout mice. On day 13, retinal-induced Tregs were adoptively transferred to mice with established CIA after second immunizations. Compared with TGF-β-induced Treg cells, retinal-induced Tregs showed increased Foxp3 expression and mediated stronger suppressive activity. Under Th17-polarizing conditions, retinal inhibited the production of IL-17 and increased the expression of Foxp3.Retinal-induced Tregs...Continue Reading

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Citations

Aug 27, 2013·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Apr 13, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Johannes FesslerChristian Dejaco
May 27, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Neng YangKuang-Yen Chou
Oct 21, 2017·The Korean Journal of Internal Medicine·Jung-Yeon LimSeok-Goo Cho
Oct 11, 2016·Cellular & Molecular Immunology·Rita DiehlJohannes Boltze
Oct 15, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ping ZhangGeoffrey R Hill

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