PMID: 6974704Jun 15, 1981Paper

Adoptive transfer of immunity induced by semi-allogeneic hybrid cells, against a murine fibrosarcoma

International Journal of Cancer. Journal International Du Cancer
B PayelleG Lespinats

Abstract

Semi-allogeneic somatic hybrid cells derived from the fusion of a C57BL/6 fibrosarcoma (MCB6-1) and A9 cells (C3H origin) were used to immunize C57BL/6 mice against the parental tumor cells. These hybrid cells expressed H-2 histocompatibility antigen of both parental cells (H-2b and H-2k), and failed to produce tumors in normal C57BL/6 mice. A single i.p. injection of hybrid cells induced anti-tumor immunity which could be transferred to normal C57BL/6 recipient mice by immune spleen or peritoneal cells; the efficient cells were T cells, as this activity was completely abrogated by treatment with anti-Thy-1-2 antiserum and complement. Among immune splenic T cells, only the light-density T cells, obtained after fractionation on Percoll gradient, were effective in the transfer of immunity. Immunity induced by the hybrid cells was specific for MCB6-1 parental tumor cells. This immunity could be transferred during two brief periods, 7 to 12 days, and 40 to 50 days, after hybrid cell injection; there appeared to be an intermediate period, 12 to 40 days after immunization, during which no immunity could be transferred. These results suggest a suppressive mechanism implicated during hybrid cell immunization and interacting with the an...Continue Reading

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Citations

Mar 31, 1999·Immunology Today·G M ShearerM Clerici
Mar 15, 2000·AIDS Research and Human Retroviruses·T LehnerO K Sharma
Aug 10, 2007·Journal of Translational Medicine·Jin YuSebastiano Gattoni-Celli
Jul 15, 1984·International Journal of Cancer. Journal International Du Cancer·B PayelleS Tlouzeau
Apr 4, 2000·Journal of Immunotherapy·D A NewtonS Gattoni-Celli
Jun 1, 2001·Nature Medicine·J W Fabre

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