PMID: 15356105Sep 10, 2004Paper

Adoptive transfer of paternal antigen-hyporesponsive T cells induces maternal tolerance to the allogeneic fetus in abortion-prone matings

The Journal of Immunology : Official Journal of the American Association of Immunologists
Li-ping JinMin-min Yuan

Abstract

The embryo expresses paternal Ags foreign to the mother and therefore has been viewed as an allograft. It has been shown that anergic T cells generated by blocking of the CD28/B7 costimulatory pathway with anti B7-1 and anti B7-2 mAbs can be transferred as suppresser cells to prevent allograft rejection. Little is known, however, about the in vivo function of anti-B7-treated T cells after their transfer into abortion-prone mice in the maintenance of materno-fetal tolerance. In the present study, abortion-prone CBA/J females mated with DBA/2 males were administered anti-B7-1 and anti-B7-2 mAbs on day 4 of gestation (murine implantation window). The anti-B7-treated T cells subsequently were adoptively transferred into abortion-prone CBA/J mice. We demonstrated that costimulation blockade with anti-B7 mAbs at the time of implantation resulted in altered allogeneic T cell response and overcame increased maternal rejection to the fetus in the CBA/JxDBA/2 system. The transferred anti-B7-treated T cells appeared to be regulatory, decreasing responsiveness and generating clonal deviation in maternal recipient T cells. The transferred CFSE-labeled T cells were found to reside in the spleen and uterine draining lymph nodes, and a few wer...Continue Reading

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Citations

Feb 17, 2006·Nature Immunology·John Trowsdale, Alexander G Betz
Mar 25, 2010·American Journal of Reproductive Immunology : AJRI·Anne LeberAna C Zenclussen
Jan 10, 2012·American Journal of Reproductive Immunology : AJRI·Mukesh K JaiswalKenneth D Beaman
Apr 14, 2010·American Journal of Reproductive Immunology : AJRI·Margaret G Petroff, Antoine Perchellet
Feb 27, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Wen-Hui ZhouDa-Jin Li
Jan 30, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Elizabeth A Bonney, Stephen A Brown
Mar 26, 2014·American Journal of Reproductive Immunology : AJRI·Anne Schumacher, Ana Claudia Zenclussen
Feb 1, 2011·American Journal of Reproductive Immunology : AJRI·Li-Ping JinDa-Jin Li
Apr 1, 2018·American Journal of Reproductive Immunology : AJRI·Hamed HajipourMohammad Nouri

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