Adoptive transfer of suppression of autoimmune response to rat male accessory glands with spleen mononuclear cells from antigen-pretreated rats

American Journal of Reproductive Immunology and Microbiology : AJRIM
M E FerroC M Riera

Abstract

The injection of the spleen mononuclear (SpM) cells, obtained from rats rendered unresponsive to autoantigen of rat male accessory glands (RAG) by pretreatment with low doses of purified fraction of RAG (containing the autoantigen), into normal syngeneic recipients markedly prevented the development of delayed type hypersensitivity (DTH) reaction to the autoantigen (suppression of the induction) (p less than 0.001). The humoral response was not altered. The control animals were rat receptors of spleen mononuclear cells from donor rats pretreated with rat lung saline extract or 0.15 M NaCl. In contrast, the transference of SpM cells from donor rats pretreated with low doses of autoantigen prior to the immunization to rats previously immunized, did not modify the expression of the immune response against the autoantigen when compared with control rats. The suppression of the induction of DTH response was also obtained when prior to the immunization, the recipients received T-cell-enriched SpM cell population from unresponsive animals (p less than 0.001), but not when they were injected with B-cell-enriched SpM cells. These results suggest that suppressor T cells capable of controlling induction of the autoimmune response against ...Continue Reading

References

Nov 1, 1985·American Journal of Reproductive Immunology and Microbiology : AJRIM·M E FerroC M Riera
Dec 1, 1971·Journal of Reproduction and Fertility·C YantornoE Vottero-Cima
Nov 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·R M Nakamura, W O Weigle
Sep 1, 1967·Endocrinology·I M Roitt, G Torrigiani
Jan 1, 1982·Journal of Immunological Methods·J M MacSweenR A Fox
Jan 1, 1984·International Archives of Allergy and Applied Immunology·E Vottero-CimaM C Pistoresi-Palencia
Jan 1, 1983·International Journal of Immunopharmacology·H M SerraC M Riera

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