ADP-dependent platelet function prior to and in the early course of pediatric liver transplantation and persisting thrombocytopenia are positively correlated with ischemia/reperfusion injury

Transplant International : Official Journal of the European Society for Organ Transplantation
Jan Schulte am EschLutz Fischer

Abstract

Little is known about the role of platelets in relation to ischemia/reperfusion injury (IRI) of the liver graft especially in children. Thrombocyte function was prospectively analysed in 21 consecutive pediatric liver transplantation (pLT) patients by platelet aggregometry secondary to adenosine diphosphate (ADP), collagen, and the von Willebrand factor activator ristocetin (VWF:rco). Post-OP serum levels of ALT were used to divide patients into groups with high (highHD, n = 8) and low (lowHD, n = 13) hepatocellular damage. Clinically, highHD-patients showed impaired plasmatic coagulation and elevated serum bilirubin levels early after pLT when compared with lowHD-patients. Further, platelet counts markedly decreased between pre-OP and postreperfusion (postrep.) in the highHD group (P = 0.003) and did not recuperate by POD6. In lowHD individuals thrombocytopenia improved from both pre-OP (P < 0.05) and postrep. (P < 0.001) respectively towards POD6. Experimental thrombocyte testing revealed that before graft reperfusion only ADP-dependent platelet aggregation correlated with reperfusion injury, thrombocytopenia and early graft function. During the first 48 h after graft reperfusion, all inducers tested demonstrated elevated pla...Continue Reading

References

Nov 1, 1989·American Journal of Hematology·J D SweeneyJ E Fitzpatrick
Sep 1, 1987·Mayo Clinic Proceedings·C A OwenR A Krom
Dec 1, 1981·Journal of Pharmacological Methods·N C Russell-SmithD C Cardinal
Sep 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R CywesS M Strasberg
Jul 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W LiuR H Glew
Dec 27, 1996·Transplantation·N KoyamadaS C Robson
Jul 1, 1997·The Australian and New Zealand Journal of Surgery·R BellA K House
Sep 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·T PiratvisuthR Williams
Jan 1, 1996·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R CywesS M Strasberg
Mar 30, 1999·Transplantation·M A ChatzipetrouA G Tzakis
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E M WolberW Jelkmann
Jul 23, 1999·Annals of the New York Academy of Sciences·S C RobsonF H Bach
Dec 1, 2001·Annals of Surgery·D C BroeringX Rogiers
Oct 14, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Jan Schulte am EschXavier Rogiers
Dec 2, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Christophe BourdeauxRaymond Reding
Aug 12, 2009·Transplant International : Official Journal of the European Society for Organ Transplantation·Youichi KawanoHideo Kawarasaki

❮ Previous
Next ❯

Citations

May 10, 2013·European Journal of Anaesthesiology·Sibylle A Kozek-LangeneckerPiet Wyffels
Nov 26, 2013·Purinergic Signalling·Geoffrey BurnstockSimon C Robson
May 31, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Burcin EkserBruno Gridelli
Mar 29, 2007·PLoS Medicine·Muhammad M Mohiuddin
Feb 16, 2016·World Journal of Gastroenterology : WJG·Mirco NacotiEzio Bonanomi
Oct 11, 2017·Frontiers in Pharmacology·Geoffrey Burnstock

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Orhan GurselOkan Ozcan
© 2021 Meta ULC. All rights reserved