ADP-ribosyl cyclase coupled with receptors via G proteins

FEBS Letters
H Higashida

Abstract

Crude cell membranes in mammalian cells contain ADP-ribosyl cyclase, which converts NAD+ to cyclic ADP-ribose. Acetylcholine either increases or inhibits this activity in NG108-15 neuronal cells and adrenal chromaffin cells in a muscarinic receptor subtype-specific manner. Activation or inhibition of the cyclase activity is mimicked by GTP and blocked by bacterial toxins. These findings suggest that hormone or neurotransmitter receptors utilize the direct signaling pathway to ADP-ribosyl cyclase via G proteins within cell membranes, analogous to the previously established transduction pathways to adenylyl cyclase and phospholipase Cbeta.

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Citations

Oct 17, 2008·Neurocritical Care·Salvatore SalomoneJohn Randall Sims
Jan 26, 2000·Journal of Neurochemistry·T HottaH Higashida
Feb 24, 2001·Journal of Neurochemistry·H HigashidaT Kato
Dec 17, 2008·Current Opinion in Nephrology and Hypertension·William J Arendshorst, Tiffany L Thai
Aug 17, 2004·The Journal of Allergy and Clinical Immunology·Michael I KotlikoffPrescott G Woodruff
Jan 7, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Deepak A DeshpandeMathur S Kannan
Nov 24, 1999·The Journal of Biological Chemistry·H HigashidaJ S Zhang
Jun 22, 1999·Cellular Signalling·A H Guse
Aug 1, 2007·Neurochemistry International·Haruhiro HigashidaMami Noda

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