ADP-ribosylarginine hydrolases and ADP-ribosyltransferases. Partners in ADP-ribosylation cycles

Advances in Experimental Medicine and Biology
J MossI J Okazaki

Abstract

Mono-ADP-ribosylation is a reversible modification of arginine residues in proteins, with NAD:arginine ADP-ribosyltransferases and ADP-ribosylarginine hydrolases constituting opposing arms of a putative ADP-ribosylation cycle. The enzymatic components of an ADP-ribosylation cycle have been identified in both prokaryotic and eukaryotic systems. The regulatory significance of the cycle has been best documented in prokaryotes. As shown by Ludden and coworkers, ADP-ribosylation controls the activity of dinitrogenase reductase in the phototropic bacterium Rhodospirillum rubrum. ADP-ribosylation of other amino acids, such as cysteine, has also been demonstrated, lending credence to the hypothesis that this modification is heterogeneous. In eukaryotes, the functional relationship between ADP-ribosyltransferases and ADP-ribosylarginine hydrolases is less well documented. The transferase-catalyzed reaction results in sterospecific formation of alpha-ADP-ribosylarginine from beta-NAD; ADP-ribosylarginine hydrolases specifically cleave the alpha-anomer, leading to release of ADP-ribose and regeneration of the free guanidino group of arginine. The two reactions can thus be coupled in vitro. Coupling in vivo is dependent on cellular localiz...Continue Reading

Citations

Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Catrine L BertholdMartin Högbom
Apr 19, 2011·The Journal of Biological Chemistry·Atsushi KasamatsuJoel Moss
Dec 11, 2013·Translational Stroke Research·Katrina OwensTibor Kristian
Sep 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·Paul O HassaMichael O Hottiger
Aug 2, 2020·The Journal of Pharmacy and Pharmacology·Francisca B M SousaJand V R Medeiros
Nov 10, 2005·The Journal of Biological Chemistry·Shunya OkaJoel Moss
Feb 26, 2020·Cancers·Hiroko Ishiwata-EndoJoel Moss
Dec 26, 2001·Chemical Reviews·X HeH W Liu Hw
Jan 29, 2010·Trends in Biochemical Sciences·Michael O HottigerFriedrich Koch-Nolte
Jul 12, 2011·Trends in Cell Biology·Simon Messner, Michael O Hottiger

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