ADP-ribosylation of actin by clostridial toxins

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

Botulism (ASM)

Botulism is a rare but serious paralytic illness caused by a nerve toxin that is produced by the bacterium clostridium botulinum. Discover the latest research on botulism here.

ADP-ribosylation of actin by clostridial toxins

Abstract

References

The complete amino acid sequence of actins from bovine aorta, bovine heart, bovine fast skeletal muscle, and rabbit slow skeletal muscle. A protein-chemical analysis of muscle actin differentiation.

Inhibition of histamine release from rat mast cells by botulinum C2 toxin

Actin involvement in exocytosis from PC12 cells: studies on the influence of botulinum C2 toxin on stimulated noradrenaline release

ADP-ribosylation of actin causes increase in the rate of ATP exchange and inhibition of ATP hydrolysis

Nonmuscle actin ADP-ribosylated by botulinum C2 toxin caps actin filaments

Inhibition of the contraction of the isolated longitudinal muscle of the guinea-pig ileum by botulinum C2 toxin: evidence for a role of G/F-actin transition in smooth muscle contraction.

Botulinum C2 toxin ADP-ribosylates actin and enhances O2- production and secretion but inhibits migration of activated human neutrophils

Clostridium perfringens iota toxin ADP-ribosylates skeletal muscle actin in Arg-177.

ADP-ribosylation of skeletal muscle and non-muscle actin by Clostridium perfringens iota toxin.

Clostridium spiroforme toxin is a binary toxin which ADP-ribosylates cellular actin

Heterogeneities of two components of C2 toxin produced by Clostridium botulinum types C and D

ADP-ribosylation of platelet actin by botulinum C2 toxin

Actin and actin-binding proteins. A critical evaluation of mechanisms and functions

The directed migration of eukaryotic cells

Botulinum C2 toxin potentiates activation of the neutrophil oxidase. Further evidence of a role for actin polymerization

Botulinum C2 toxin ADP-ribosylates actin

Rate constants for the reactions of ATP- and ADP-actin with the ends of actin filaments

12-fold difference between the critical monomer concentrations of the two ends of actin filaments in physiological salt conditions

Citations

ADP-ribosylation of actins in fibroblasts and myofibroblasts by botulinum C2 toxin: influence on microfilament morphology and migratory behavior

Clostridial ADP-ribosylating toxins: effects on ATP and GTP-binding proteins

Cytotoxic effects by microinjection of ADP-ribosylated skeletal muscle G-actin in PtK2 cells in the absence of Clostridium perfringens iota toxin

C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins

Exploring the role of host cell chaperones/PPIases during cellular up-take of bacterial ADP-ribosylating toxins as basis for novel pharmacological strategies to protect mammalian cells against these virulence factors

Studies on the active-site structure of C3-like exoenzymes: involvement of glutamic acid in catalysis of ADP-ribosylation

The structure of the F-actin filament and the actin molecule

Function of the cytoskeleton in human neutrophils and methods for evaluation

The Rho-ADP-ribosylating C3 exoenzyme from Clostridium botulinum and related C3-like transferases

Ophidian envenomation strategies and the role of purines

Clostridium perfringens iota-toxin, ADP-ribosyltransferase: structure and mechanism of action

Modulation of tight junction function by G protein-coupled events

Perturbation and exploitation of host cell cytoskeleton by periodontal pathogens

Obstructing toxin pathways by targeted pore blockage.

Mutational analysis of arginine 177 in the nucleotide binding site of beta-actin

Identification of an iron-sulfur cluster that modulates the enzymatic activity in NarE, a Neisseria meningitidis ADP-ribosyltransferase.

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

Bacterial ADP-ribosylating toxins: molecular structures and signal transducing functions

Mechanisms of the cytopathic action of actin-ADP-ribosylating toxins

ADP-ribosylation of actin isoforms by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin

Cysteine-specific ADP-ribosylation of actin

ADP-ribosylation of Arg28 and Arg206 on the actin molecule by chicken arginine-specific ADP-ribosyltransferase

Photorhabdus luminescens toxins ADP-ribosylate actin and RhoA to force actin clustering

Intracellular trafficking of Clostridium perfringens iota-toxin b.

Clostridium perfringens iota-toxin b induces rapid cell necrosis.

Binding component of Clostridium perfringens iota-toxin induces endocytosis in Vero cells.

The host cell chaperone Hsp90 is necessary for cytotoxic action of the binary iota-like toxins.

Binding and internalization of Clostridium perfringens iota-toxin in lipid rafts

A type VI secretion system effector protein, VgrG1, from Aeromonas hydrophila that induces host cell toxicity by ADP ribosylation of actin.

Characterization of the enzymatic component of Clostridium perfringens iota-toxin.

Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins

Role of Botulinum Toxin Type-A (BTX-A) in the Management of Trigeminal Neuralgia

Role of actin depolymerization in the surfactant secretory response of alveolar epithelial type II cells

Adenosine diphosphate-ribosylation of G-actin by botulinum C2 toxin increases endothelial permeability in vitro

Tailored ß-cyclodextrin blocks the translocation pores of binary exotoxins from C. botulinum and C. perfringens and protects cells from intoxication.

Clostridium perfringens iota-toxin: structure and function.

Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets

Tailored cyclodextrin pore blocker protects mammalian cells from clostridium difficile binary toxin CDT

About lipids and toxins

Cyclophilin-facilitated membrane translocation as pharmacological target to prevent intoxication of mammalian cells by binary clostridial actin ADP-ribosylated toxins

Analysis of the catalytic site of the actin ADP-ribosylating Clostridium perfringens iota toxin

New insights into the mode of action of the actin ADP-ribosylating virulence factors Salmonella enterica SpvB and Clostridium botulinum C2 toxin

Role of Ca2+-binding motif in cytotoxicity induced by Clostridium perfringens iota-toxin

Biological characterization of a new type III secretion system effector from a clinical isolate of Aeromonas hydrophila-part II

Actin

A family of killer toxins. Exploring the mechanism of ADP-ribosylating toxins

Side chain specificity of ADP-ribosylation by a sirtuin.

Fibronectin receptors are functional on mitotic Chinese hamster ovary cells

Protein toxins with intracellular targets

The cytotoxic effect of diphtheria toxin on the actin cytoskeleton

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Botulinum C2 toxin ADP-ribosylates actin

Clostridium spiroforme toxin is a binary toxin which ADP-ribosylates cellular actin

Characterization of the enzymatic component of Clostridium perfringens iota-toxin.