Adrenal 11-beta hydroxysteroid dehydrogenase activity in response to stress

Canadian Journal of Physiology and Pharmacology
Marisa Laura ZallocchiMaría Cristina Damasco

Abstract

This work studied the effect of stresses produced by simulated gavage or gavage with 200 mmol/L HCl two hours before adrenal extraction, on the activities of the 11beta-hydroxysteroid dehydrogenase 1 and 11beta-hydroxysteroid dehydrogenase 2 isoforms present in the rat adrenal gland. These activities were determined on immediately prepared adrenal microsomes following incubations with 3H-corticosterone and NAD+ or NADP+. 11-dehydrocorticosterone was measured as an end-product by TLC, and controls were adrenal microsomes from rats kept under basal (unstressed) conditions. 11beta-hydroxysteroid dehydrogenase 1 activity, but not 11beta-hydroxysteroid dehydrogenase 2 activity, was increased under both stress-conditions. Homeostatically, the stimulation of 11beta-hydroxysteroid dehydrogenase 1 activity would increase the supply of glucocorticoids. These, in turn, would activate the enzyme phenylethanolamine N-methyl transferase, thereby improving the synthesis of epinephrine as part of the stress-response.

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Citations

May 15, 2013·PloS One·Ricardo Borges MachadoDeborah Suchecki
Jan 16, 2007·Canadian Journal of Physiology and Pharmacology·María Eugenia AltunaMaría Cristina Damasco
Jul 9, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Shengxian LiYiting Cai
May 14, 2020·Stress : the International Journal on the Biology of Stress·Alexey SarapultsevVadim Tseilikman
Feb 7, 2021·General and Comparative Endocrinology·Michelle A Rensel, Barney A Schlinger

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