PMID: 8969940Nov 1, 1996Paper

Adrenal 11 beta-hydroxysteroid dehydrogenase

Endocrine Research
M ShimojoP M Stewart

Abstract

11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the interconversion of cortisol (F) to inactive cortisone (E) in man (corticosterone (B) to 11-dehydrocorticosterone (A) in rodents) and plays a crucial role in regulating corticosteroid hormone action. Two isoforms of this enzyme have been characterized; a low affinity NADP(H)-dependent enzyme (11 beta-HSD1) and a high affinity NAD-dependent dehydrogenase (11 beta-HSD2). We have analysed the expression of 11 beta-HSD in the rodent and human adrenal gland and have investigated its role with respect to glucocorticoid-mediated catecholamine biosynthesis. Our studies indicated higher expression of 11 beta-HSD2 mRNA in male versus female intact mouse adrenal. Both 11 beta-HSD isoforms were detected in intact male rat adrenal homogenates. For the 11 beta-HSD1 isoform, NADPH-dependent oxo-reductase activity exceeded that of NADP-dependent dehydrogenase activity (188 versus 98 pmol/mg.protein.hr). In situ hybridisation studies indicated specific localisation of 11 beta-HSD1 mRNA to cells at the corticomedullary junction. 11 beta-HSD2 mRNA was uniformly distributed across the cortex and was low/absent in the medulla. Administration of glycyrrhizic acid in vivo (> 100 mg/kg fo...Continue Reading

References

Jan 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C B WhorwoodP M Stewart
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B GrimaJ Mallet
Jun 1, 1995·Molecular and Cellular Endocrinology·K Yang, S G Matthews
Nov 1, 1994·Molecular and Cellular Endocrinology·A L AlbistonZ S Krozowski
Apr 1, 1993·The American Journal of Physiology·R A YazigiO H Lowry

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Citations

Jul 1, 1999·Clinical and Experimental Pharmacology & Physiology·O AinsahB A Khalid
Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A JamiesonJ M Connell
Feb 24, 2001·Journal of Hypertension·Y KomiyamaH Takahashi
Jan 15, 1999·Endocrine Research·C L CoulterR D Gordon
Jul 1, 1999·Clinical and Experimental Pharmacology & Physiology·O AinsahB A Khalid
Sep 24, 2004·Canadian Journal of Physiology and Pharmacology·Marisa ZallocchiMaría C Damasco
Feb 7, 2021·General and Comparative Endocrinology·Michelle A Rensel, Barney A Schlinger
Aug 7, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·R Nass, M O Thorner

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