Adrenal activity and metabolic risk during randomized escitalopram or placebo treatment in PCOS

Endocrine Connections
Dorte GlintborgMarianne Andersen

Abstract

Polycystic ovary syndrome (PCOS) is associated with insulin resistance, adrenal hyperactivity and decreased mental health. We aimed to investigate the changes in adrenal activity, metabolic status and mental health in PCOS during treatment with escitalopram or placebo. Forty-two overweight premenopausal women with PCOS and no clinical depression were randomized to 12-week SSRI (20 mg escitalopram/day,n = 21) or placebo (n = 21). Patients underwent clinical examination, fasting blood samples, adrenocorticotroph hormone (ACTH) test, 3-h oral glucose tolerance test (OGTT) and filled in questionnaires regarding mental health and health-related quality of life (HRQoL): WHO Well-Being Index (WHO-5), Major Depression Inventory (MDI), Short Form 36 (SF-36) and PCOS questionnaire. Included women were aged 31 (6) years (mean (s.d.)) and had body mass index (BMI) 35.8 (6.5) kg/m2and waist 102 (12) cm. Escitalopram was associated with increased waist (median (quartiles) change 1 (0; 3) cm),P = 0.005 vs change during placebo and increased cortisol levels (cortisol 0, cortisol 60, peak cortisol and area under the curve for cortisol during ACTH test), allP < 0.05 vs changes during placebo. Escitalopram had no significant effect on measures of...Continue Reading

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Citations

Sep 29, 2019·The Australian and New Zealand Journal of Psychiatry·Abigail S McGovernGal Winter
May 15, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Jiaqi ZhangBing He

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