PMID: 8580904Sep 1, 1995Paper

Adrenal changes in murine pulmonary tuberculosis; a clue to pathogenesis?

FEMS Immunology and Medical Microbiology
R Hernandez-PandoG A Rook

Abstract

When mice were infected with virulent Mycobacterium tuberculosis H37Rv by the intra-tracheal route, there was an early phase of adrenal hyperplasia, histologically resembling the adrenocorticotropic (ACTH)-driven changes seen in Cushing's disease. This was followed at 3 weeks by progressive atrophy until the weight of the adrenals was approximately 50% of that seen in control uninfected mice, in spite of the fact that the adrenals were not infected. All layers of the adrenal cortex were affected, but the medulla was normal. Electron microscope studies revealed apoptosis. The switch from adrenal hyperplasia to adrenal atrophy corresponded to onset of an IgG1 response recognising a wide range of mycobacterial components in Western blots. Delayed type hypersensitivity (DTH) responses were seen throughout, but differed in their sensitivity to TNF alpha. Thus if TNF alpha was injected at 24 h into DTH sites elicited during the phase of adrenal hyperplasia, there was no increment in swelling at 48 h. However similar injections of TNF alpha resulted in a doubling of the swelling in DTH sites elicited during the phase of adrenal atrophy. This may be relevant to the pathogenesis of cytokine-mediated tissue damage in the human disease. I...Continue Reading

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Citations

Oct 24, 1998·Domestic Animal Endocrinology·J F Griffin, A J Thomson
Jan 1, 1996·Annual Review of Microbiology·G A Rook, R Hernandez-Pando
Dec 24, 2002·Infection and Immunity·Fabio SánchezCatharina Lavebratt
Apr 17, 2004·Clinical and Experimental Immunology·R A FabreS Estrada Parra
Jul 25, 2012·Annals of the New York Academy of Sciences·Luciano D'AttilioMaría Luisa Bay
Jul 17, 2004·International Journal of Experimental Pathology·Alexander Pedroza-GonzálezLeopoldo Flores-Romo
Jun 5, 1998·Experimental and Molecular Pathology·R Hernández-PandoV Madrid-Marina
Sep 10, 2016·Journal of Neuroimmunology·Jorge Barrios-PayánRogelio Hernandez-Pando
Jun 28, 2019·Frontiers in Endocrinology·Mario ZetterRogelio Hernández-Pando
Aug 27, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Rogelio Hernandez-PandoDiana Aguilar
Dec 17, 2020·International Journal of Molecular Sciences·Jacqueline V Lara-EspinosaRogelio Hernández-Pando
Mar 9, 2021·Journal of Leukocyte Biology·Octavio Ramos-EspinosaRogelio Hernández-Pando
Apr 19, 2021·Clinical and Experimental Immunology·Manuel Othoniel López-TorresRogelio Hernández-Pando

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