PMID: 12773139May 30, 2003Paper

Adrenal function during coronary artery bypass grafting

European Journal of Endocrinology
Christoph HenzenVerena A Briner

Abstract

To assess adrenal function in patients undergoing coronary artery bypass grafting (CABG) by means of the low-dose (1 microg) ACTH test, and to correlate the adrenal function with clinical outcome. During a 5-Month period we prospectively included 45 patients undergoing elective CABG with cardiopulmonary bypass and without symptoms of endocrine disease. Low-dose (1 microg) ACTH tests were performed on the day before surgery (day -1), immediately after the operation (day 0), on the two subsequent days in the intensive care unit (day 1 and day 2), and on the day of discharge from the hospital. A number of clinical, hemodynamic and laboratory parameters were monitored throughout. On day -1, 75% of the study patients had normal stimulated plasma cortisol concentrations. Eleven patients (25%) had an impaired adrenal response to 1 microg ACTH. The stimulated plasma cortisol concentrations in patients who had an inadequate adrenal response on day -1 remained significantly reduced on day 1 (756+/-205 vs 949+/-259 nmol/l, P=0.03) (mean+/-s.d.), day 2 (644 (580-793) vs 885 (713-1087), P=0.03) (median (interquartile range)), and on the day of discharge (698+/-201 vs 854+/-186, P=0.05). In patients with a normal adrenal response in the preo...Continue Reading

Citations

Jan 25, 2012·Interactive Cardiovascular and Thoracic Surgery·Celma D'SilvaDumbor Ngaage
Apr 7, 2011·Critical Care : the Official Journal of the Critical Care Forum·Alexander KochKai Zacharowski
Mar 12, 2011·The Veterinary Clinics of North America. Equine Practice·Kelsey A Hart, Michelle H Barton
Mar 9, 2010·Current Problems in Surgery·Avihu Z GazitA Thomas Pezzella
Sep 20, 2007·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Moto KashiwabaraTakashi Tajiri
Jul 24, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Jeffrey G WilliamsThomas H Hintze
Mar 8, 2007·The Journal of Clinical Endocrinology and Metabolism·Mirjam Christ-CrainAshley B Grossman
Jan 2, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Yun-Tai YaoJie Ma
May 1, 2021·Journal of the Endocrine Society·Stefan FischliChristoph Henzen

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