PMID: 6108152Dec 8, 1980Paper

Adrenal influence on tyrosine hydroxylase activity in superior cervical ganglion

Brain Research
K A Markey, P Y Sze

Abstract

The involvement of adrenal hormones as regulatory factors in maintaining physiological levels of tyrosine hydroxylase (TH) was examined in mouse superior cervical ganglion. Following bilateral adrenalectomy, TH activity in the ganglion fell at a slow but steady rate, reaching 60-65% of the control levels after 2 weeks. Decentralization is known also to reduce TH activity in the ganglion. The effects of adrenalectomy and decentralization were therefore compared, and they were found to be additive, indicating different mechanisms in the two cases. The reduction of TH activity following adrenalectomy was not prevented by replacement with corticosterone (0.5 mg/kg, daily). However, replacement with epinephrine (4 mg/kg, daily) completely prevented the fall of TH activity in adrenalectomized animals. Isoproterenol, a beta-adrenergic receptor agonist, was as effective as epinephrine in preventing the reduction of TH activity following adrenalectomy. Furthermore, in intact animals, chronic administration of SKF 64139, an inhibitor of adrenal PNMT which depletes circulating epinephrine levels, also reduced ganglionic TH activity to the same level as that after adrenalectomy. These results indicate that epinephrine, but not corticostero...Continue Reading

References

Jun 11, 1976·Brain Research·C Mytilineou, I B Black
Apr 25, 1977·Biochemical and Biophysical Research Communications·K NagaiahG Guroff
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·U Otten, H Thoenen
Apr 1, 1970·European Journal of Pharmacology·R A MuellerJ Axelrod
Sep 1, 1964·Analytical Biochemistry·T NAGATSUS UDENFRIEND

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Citations

Aug 1, 1982·Biulleten' eksperimental'noĭ biologii i meditsiny·A V GorbunovaV V Portugalov
Jan 1, 1981·Journal of Neural Transmission·D P CardinaliP V Gejman
Sep 1, 1981·Neuropharmacology·J W Dailey, H D Battarbee
Dec 16, 1982·Brain Research·A C Towle, P Y Sze
May 1, 1989·Journal of Neuroscience Research·S R D'MelloB B Kaplan

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