PMID: 9545115Apr 17, 1998Paper

Adrenal insufficiency after recurrent post-partum thyroiditis (post-partum Schmidt syndrome): a case report

Thyroid : Official Journal of the American Thyroid Association
H MehtaP G Walfish

Abstract

Polyglandular autoimmune syndrome (PGAS) type 2 (Schmidt syndrome) is characterized by the association of primary adrenocortical insufficiency with autoimmune thyroid disease, and/or insulin-dependent diabetes mellitus (IDDM). In this report we describe the occurrence of two episodes of post-partum thyroiditis (PPT) after a first and second pregnancy as well the development acutely of adrenal insufficiency after a second pregnancy. A family history of autoimmune thyroid disease and IDDM as well as positive antiadrenal and antithyroid antibodies and HLA typing is evidence for an underlying polyendocrine autoimmune syndrome. This case report provides further evidence that the immune system that is suppressed in pregnancy to tolerate the fetal allograft can rebound post-partum to unmask polyendocrine autoimmune disorders such as adrenalitis and PPT in susceptible women.

References

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Citations

Jun 30, 2000·Endocrinology and Metabolism Clinics of North America·A Stagnaro-Green
Oct 30, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Olga Gumieniak MD, Alan P Farwell MD
Apr 29, 1999·Current Opinion in Obstetrics & Gynecology·J H Mestman

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