Adrenal insufficiency attributable to adrenal hemorrhage: long-term follow-up with reference to glucocorticoid and mineralocorticoid function and replacement.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Maryam Jahangir-HekmatLuis A Llerena

Abstract

To describe the long-term follow-up of acute adrenal insufficiency attributable to bilateral adrenal hemorrhage. We performed a retrospective review of medical records of four patients who underwent follow-up for 6(1/2) to 19 years. Despite published reports of more than 500 patients with bilateral massive adrenal hemorrhage through 2001, no long-term data assessing the continuing requirements for glucocorticoid and mineralocorticoid replacement are available. After follow-up of four patients with acute bilateral adrenal hemorrhage and glucocorticoid insufficiency for 6(1/2) to 19 years, we document the absence of need for long-term mineralocorticoid replacement on the basis of no occurrence of postural hypotension, normal electrolytes, normal baseline or cosyntropin-stimulated serum aldosterone levels, and generally, though not invariably, normal plasma renin activity levels. We further document the improvement in either or both baseline and cosyntropin-stimulated serum cortisol levels in three of the four patients and the ability of one patient to function normally without cortisol replacement for 4 years. Adrenal histologic findings in this last-mentioned patient revealed previously undescribed changes consistent with regene...Continue Reading

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Citations

Jan 1, 2009·Current Urology Reports·Daniel R Simon, Michael A Palese
Oct 16, 2009·Cases Journal·Aoife M EganRonan Waldron
Sep 13, 2008·Journal of Endocrinological Investigation·L C C J Smans, P M J Zelissen
Feb 20, 2007·The Journal of Emergency Medicine·Michalis K PicolosPhilip R Orlander
Apr 22, 2011·Internal Medicine Journal·J Z ShenJ T Ho
Jun 12, 2020·AACE Clinical Case Reports·Rashika BansalMohamed K M Shakir
Sep 1, 2021·The British Journal of Radiology·Mohamed BadawyKhaled M Elsayes

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Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.

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