PMID: 1895Dec 19, 1975

Adrenal-like Leydig cells (author's transl)

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
G MikuzM Herbst

Abstract

Adrenal-like lipoid-rich Leydig cells, which could be found in a cryptorchid testis, were investigated by light and electronmicroscopy. There were nodular and diffuse proliferation of these adrenal-like cells in the interstitium of the testis. Electronmicroscopically these cells are fasciculated and characterized by large liposomes, many tubulovesicular mitochondria, and a large smooth endoplasmatic reticulum. But the presence of crystals of Reinke in these cells underlined their relationship to Leydig cells. The clinical history of this case is characterised by an extreme adipositas (167 kg) and high urinary estrogenexcretion. This excretion could be suppressed with dexamethasone and stimulated with HCG. After orchiectomy estrogen excretion decreased for 4 months and then increased again, after ACTH stimulation performed by reason of adrenal insufficiency. At this time there is no evidence of adrenal tumor; in the contralateral, scrotal testis, spermiogenesis and Leydig cells are without pathologic changes as revealed by biopsy.

Related Concepts

Corticotropin
Unilateral Cryptorchidism
Protoplasm
Oradexon
Endoplasmic Reticulum
Estrogen Effect
Hydroxycorticosteroids
Structure of Interstitial Cell of Leydig
Niosomes
Mitochondria

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.

Related Papers

Archivos españoles de urología
M Medina PérezM Sánchez González
Revista médica de Chile
T VidalR Reyes
Virchows Archiv. B, Cell Pathology Including Molecular Pathology
M Nistal, R Paniagua
Italian Journal of Anatomy and Embryology = Archivio Italiano Di Anatomia Ed Embriologia
S MakabeP M Motta
Hinyokika kiyo. Acta urologica Japonica
Toyofumi AbeKatsuyuki Aozasa
© 2021 Meta ULC. All rights reserved