Adrenal medullary transplants attenuate sensorimotor dysfunction in rats with peripheral neuropathy

Pharmacology, Biochemistry, and Behavior
J B Siegan, Jacqueline Sagen

Abstract

Previous work in our laboratory has demonstrated that adrenal medullary transplants into the spinal subarachnoid space can alleviate neuropathic pain behaviors. The purpose of this study was to test the possibility that motor, as well as, sensory dysfunction is reduced by adrenal medullary transplants. Peripheral neuropathy was induced by a chronic constriction injury (CCI) of the sciatic nerve of rats. In addition to exaggerated responses to noxious and innocuous stimuli characteristic of peripheral nerve injury, severe impairment of hindpaw placing and grasping reflexes following CCI was observed. Two weeks following CCI, either adrenal medullary or control striated muscle tissue was implanted into the spinal subarachnoid space. Adrenal medullary, but not control transplants, produced significant restoration of hindlimb reflex function in animals with peripheral nerve injury. This was reversed by pretreatment with the alpha-adrenergic antagonist phentolamine, but not the opiate antagonist naloxone, suggesting a role for catecholamines secreted by the implanted cells in reflex recovery. Adrenal medullary transplants also attenuated hyperalgesia and allodynia resulting from nerve injury. These results indicate that adrenal medu...Continue Reading

References

Nov 1, 1990·Experimental Neurology·W J FreedJ B Becker
Jan 1, 1989·Brain Research Bulletin·A YakovleffA Privat
Dec 1, 1987·Neuroscience·J C Holstege, H G Kuypers
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J SagenH B Pollard
Feb 14, 1973·Brain Research·H Forssberg, S Grillner
Apr 1, 1994·Journal of Neural Transplantation & Plasticity·B E PulfordL R Whalen
Jan 1, 1994·Journal of Neural Transplantation & Plasticity·H Wang, J Sagen
Jan 1, 1994·Brain Research Bulletin·S I FungC D Barnes

❮ Previous
Next ❯

Citations

Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·A T HamaJ Sagen
Jul 30, 2008·The European Journal of Neuroscience·Mark R HutchinsonLinda R Watkins
Nov 6, 2012·Life Sciences·Mónica Ambriz-TututiRené Drucker-Colín

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.