Abstract
Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma with a dismal outcome. Most patients relapse in intracranial sites and <5% of patients relapse in extracranial sites. Here, we present the first case of PCNSL with an adrenal relapse. A 72-year-old woman, first presented 7 years ago with complaints of headache and dizziness. Enhanced magnetic resonance imaging revealed the mass within the splenium of the corpus callosum. On histological examination, there was a diffuse growth pattern of neoplastic cells in the brain biopsy. Immunohistochemistry and flow cytometric analysis demonstrated that the neoplastic cells were of B-cell lineage. The patient underwent methotrexate-based chemotherapy and whole-brain radiotherapy after the initial diagnosis of primary central nervous system-large B-cell lymphoma (CNS-DLBCL). After 4 years of clinical remission, the patient was diagnosed with endometrial cancer. Interestingly, a radiological study following the treatment of endometrial cancer demonstrated a right adrenal mass, which was suspicious for malignancy. Morphologic examination and immunohistochemistry studies confirmed the diagnosis of diffuse large B-cell lymphoma. A fluorescent in situ hybridiza...Continue Reading
References
Feb 5, 2000·Journal of Neurosurgery·B BatailleF Lapierre
Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C SoussainV Leblond
Nov 27, 2002·Neurology·Rose LaiLisa M DeAngelis
Jan 13, 2004·Clinical Lymphoma·Andrew P Grigg, Joseph M Connors
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tamara N ShenkierJoseph M Connors
May 16, 2006·Journal of Neuro-oncology·Kristoph JahnkeUNKNOWN German Primary Central Nervous System Lymphoma Study Group
Apr 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carole SoussainUNKNOWN Société Française de Greffe de Moëlle Osseuse-Thérapie Cellulaire
May 21, 2008·Endocrine Journal·Alexandra OzimekThomas Mussack
Sep 22, 2009·Lancet·Andrés J M FerreriUNKNOWN International Extranodal Lymphoma Study Group (IELSG)
Mar 5, 2011·Neuro-oncology·Lakshmi NayakLisa M DeAngelis
Jul 14, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gregory M CoteYi-Bin Chen
Sep 20, 2011·Clinical and Experimental Medicine·Franca FalzettiRoberto Ria
Sep 18, 2012·Neuro-oncology·Michael WellerUNKNOWN German PCNSL Study Group
Nov 1, 2012·Neuro-oncology·Therese A DolecekCarol Kruchko
Nov 13, 2012·Haematologica·Jacoline E BrombergMartin J van den Bent
Dec 18, 2012·Haematologica·Agnieszka KorfelLars Fischer
Aug 22, 2013·Blood·James L RubensteinPatrick Treseler
May 20, 2014·British Journal of Haematology·Chia-Ching WangJames L Rubenstein
Jun 28, 2014·Current Hematologic Malignancy Reports·Elizabeth H PhillipsKate Cwynarski
Apr 16, 2017·Journal of Medical Case Reports·Nanik RamNajmul Islam