PMID: 3364800Apr 1, 1988Paper

Adrenaline-induced changes in serum electrolytes, ECG, and blood pressure, with Ca-blockade pretreatment

B W JohanssonO Svensson


Adrenaline infusions (AI) (0.5 micrograms adrenaline per 10 kg body weight per minute over 120 minutes) were given weekly for three weeks to 20 healthy male volunteers aged twenty-one to thirty-eight years. The AI was given after three days' treatment with diltiazem (D), verapamil (V), or placebo (PI) in a single-blind fashion. After pretreatment with Pl, serum potassium (s-K) decreased from 3.93 +/- 0.30 mmol/L (M +/- SD) to 3.33 +/- 0.31 (P less than 0.001) with the greatest change 69.75 +/- 46.24 minutes after the start of the AI. Corresponding values for s-Mg were 0.84 +/- 0.06 to 0.78 +/- 0.05 (P less than 0.01) and 106.50 +/- 36.71 minutes, for s-Ca 2.40 +/- 0.07 to 2.30 +/- 0.08 (P less than 0.01) and 103.50 +/- 36.06 minutes, for s-P 1.05 +/- 0.17 to 0.91 +/- 0.17 (P less than 0.02) and 80.25 +/- 47.25 minutes, and for s-urate 344.79 +/- 50.55 to 329.26 +/- 47.80 (P greater than 0.05) and 63.95 +/- 46.05 minutes. After pretreatment with D, AI produced similar electrolyte changes as after Pl, but the rise in blood glucose was slightly more pronounced and the drop in s-urate less pronounced. The heart rate (HR) before AI after pretreatment with D was lower than after Pl, but the increase during the AI was of the same magn...Continue Reading


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