PMID: 11899430Mar 20, 2002Paper

Adrenaline suppression of the macrophage nitric oxide response to lipopolysaccharide is associated with differential regulation of tumour necrosis factor-alpha and interleukin-10

Immunology
R B ZinyamaL B Sigola

Abstract

Adrenaline is a catecholamine hormone secreted by the adrenal medulla in response to acute stress. Previous studies have shown that adrenaline suppresses the nitric oxide (NO) response of murine macrophages (M phi s) stimulated in vitro with lipopolysaccharide (LPS). We have now extended these studies to examine the effects of adrenaline on the production of tumour necrosis factor alpha (TNF-alpha) and interleukin-10 (IL-10). Our results showed that NO, TNF-alpha and IL-10 were concurrently produced following in vitro LPS (10 micrograms/ml) stimulation of murine peritoneal M phi s. Adrenaline suppressed both NO and TNF-alpha with concomitant up-regulation of the IL-10 response above that seen with LPS alone. In this in vitro model of LPS stimulation we demonstrated that TNF-alpha was required for NO production, as the TNF-alpha neutralizing monoclonal antibody, TN3.19.12, abolished the response; in contrast, IL-10 suppressed NO. In order to determine any functional consequence of adrenaline-mediated IL-10 augmentation on NO production, M phi s were stimulated with LPS and specific neutralizing anti-IL-10 antibodies were added to the cultures. The LPS NO response was suppressed to 43% of the control value by adrenaline (10(-8) M...Continue Reading

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Citations

Jul 6, 2010·European Journal of Applied Physiology·Hiromi YanoDaisuke Shiva
Mar 31, 2011·Journal of Tropical Pediatrics·G J Ebrahim
Jul 1, 2005·Shock·Carson C ChowYoram Vodovotz
Mar 19, 2013·Respiratory Research·Pauline Barbera van de Weert-van LeeuwenJeffrey Matthijn Beekman
Nov 20, 2009·The International Journal of Neuroscience·Joseph Prandota
Jul 3, 2010·Expert Review of Clinical Immunology·Bu'Hussain HayeeAnthony W Segal
Nov 27, 2010·The Journal of Surgical Research·Quan DuZheng-Guo Wang
Dec 9, 2008·Fertility and Sterility·J C TrussellRichard S Legro
Jun 29, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Simone HoegerBenito A Yard
Feb 16, 2005·Biochemical Pharmacology·Dalya Abdulla, Kenneth W Renton
Jul 29, 2005·Pathology, Research and Practice·Dimitrios J KondomerkosPanagiotis Kanavaros
Feb 4, 2014·Seminars in Immunology·Mark K LukewichAlan E Lomax
Feb 5, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mark K Lukewich, Alan E Lomax
Jan 11, 2005·Lancet·Djillali AnnaneJean-Marc Cavaillon

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