Adrenarche: a cell biological perspective

The Journal of Endocrinology
Peter J Hornsby

Abstract

Adrenarche is a cell biological and endocrinological puzzle. The differentiation of the zona reticularis in childhood in humans requires special techniques for study because it is confined to humans and possibly a small number of other primates. Despite the rapid progress in the definition of adrenocortical stem/progenitor cells in the mouse, the factors that cause the differentiation of adrenocortical cells into zonal cell types have not been identified. There are, however, many candidates in the Wnt, Hedgehog, and other families of signaling molecules. A suitable system for identifying authentic stem cells, capable of differentiation into all zones, has yet to be developed. It is proposed here that the in vitro differentiation of pluripotent cells, combined with appropriate in vitro and in vivo methods for validating authentic adrenocortical stem cells, is a promising approach to solving these questions.

References

Aug 1, 1987·The Journal of Experimental Zoology·P M Iannaccone, W C Weinberg
Apr 1, 1966·The Journal of Endocrinology·J W Dobbie, T Symington
Jan 1, 1980·Endocrine Reviews·L N Parker, W D Odell
Jul 1, 1997·Molecular and Cellular Biology·P A CrawfordJ Milbrandt
Nov 14, 2001·Reviews in Endocrine & Metabolic Disorders·P J Hornsby
Jul 20, 2002·Trends in Endocrinology and Metabolism : TEM·William E RaineyJ Ian Mason
Jan 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Przemyslaw BlyszczukAnna M Wobus
Sep 3, 2004·Science of Aging Knowledge Environment : SAGE KE·Peter J Hornsby
Aug 19, 2006·American Journal of Human Biology : the Official Journal of the Human Biology Council·Benjamin Campbell
Sep 19, 2006·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M Chen, P J Hornsby
Sep 24, 2008·Annual Review of Physiology·Laurens G van der Flier, Hans Clevers
Nov 26, 2008·The Journal of Pathology·S BrabletzT Brabletz
Apr 2, 2009·The Journal of Clinical Endocrinology and Metabolism·Yasuhiro NakamuraWilliam E Rainey
May 1, 2009·Endocrine Reviews·Alex C KimGary D Hammer
May 29, 2009·The Journal of Endocrinology·J Christina PattisonIan M Bird
Jun 19, 2009·Genesis : the Journal of Genetics and Development·Saunders Ching, Eric Vilain
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Peter KingEd Laufer
Jan 29, 2010·Nature·Thomas VierbuchenMarius Wernig
Feb 2, 2010·Endocrinology·Chen-Che Jeff HuangHumphrey Hung-Chang Yao
Apr 17, 2010·Hormone Research in Pædiatrics·Ze'ev Hochberg
Jun 8, 2010·Cell Transplantation·Cibele C CardosoPeter J Hornsby
Jun 10, 2010·Tissue Engineering. Part a·Robert A AllenJennifer B Ogilvie
Nov 26, 2010·Molecular and Cellular Endocrinology·Michelle A Wood, Gary D Hammer
Feb 5, 2011·Nature Reviews. Gastroenterology & Hepatology·Sebastian S ZekiNicholas A Wright
May 26, 2011·Neuron·Steve S W HanKevin C Eggan
Aug 13, 2011·Archives of Disease in Childhood·Rachel M WilliamsIeuan A Hughes

❮ Previous
Next ❯

Citations

Sep 26, 2014·International Journal of Endocrinology·Marco MarinoManuela Simoni
Jun 14, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Raimo Voutilainen, Jarmo Jääskeläinen
Aug 5, 2020·The Journal of Clinical Endocrinology and Metabolism·Jae Hyun KimChoong Ho Shin
Jun 18, 2018·Human Nature : an Interdisciplinary Biosocial Perspective·Timothy S McHalePeter B Gray
Mar 3, 2021·Cell and Tissue Research·Felix FriedrichHolger S Willenberg
Mar 8, 2021·Molecular and Cellular Endocrinology·Typhanie Dumontet, Antoine Martinez
May 21, 2021·Nature Reviews. Endocrinology·Rodanthi Lyraki, Andreas Schedl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

© 2021 Meta ULC. All rights reserved