PMID: 8961302Nov 15, 1996Paper

Adrenergic activation of phospholipase D in primary rat astrocytes

Neuroscience Letters
R GonzalezJ Klein

Abstract

Phospholipase D (PLD) activity was investigated in astrocytes prepared from newborn rat cerebral cortex using the transphosphatidylation assay. Basal PLD activity was measurable and was found to be enhanced by ATP, carbachol and noradrenaline. The activation by noradrenaline (EC50, 0.68 microM) was mimicked by methoxamine (EC50, 65 microM), an alpha 1-specific adrenergic agonist, and was inhibited by prazosine, an alpha 1-specific adrenergic antagonist. Clonidin, an alpha 2-adrenergic agonist, slightly lowered PLD activity whereas beta-adrenergic drugs were without effect. Experiments with mitogens indicate that PLD activation in astrocytes may be involved in the control of astrocytic cell proliferation.

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Citations

Jan 13, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·K KötterJ Klein
Oct 28, 1998·Journal of Physiology, Paris·K Löffelholz
Mar 29, 2002·The European Journal of Neuroscience·E-J LeeS-J Oh
Dec 27, 2005·Neuroscience Letters·Jeeyoung LeeTaekyun Shin
Mar 14, 2001·American Journal of Physiology. Cell Physiology·J C OprinsJ A Groot

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