Adrenergic activity of ortho-, meta-, and para-octopamine

Pharmacology
M J FreglyC M Williams

Abstract

DL-o-, and p-octopamine were tested for beta- and alpha-adrenergic activity in rats. When compared to DL-isoproterenol, a beta-adrenergic agonist, all three isomers failed to show significant beta-adrenergic activity as assessed by intiation of thirst and by increase in tail skin temperature. All three isomers increased mean blood pressure in pentolinium-blocked rats. Of the three isomers, m-octopamine possessed the greatest alpha-adrenergic activity. When the responses were compared with those induced by L-norepinephrine, the order of activities was: 1:0.01 :0.0005 :0.0007 for norepinephrine, m-, p- and o-octopamine, respectively. Thus, DL-m-octopamine has about 1/100th the alpha-adrenergic activity of L-norepinephrine.

Citations

Jan 22, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·J R CrowleyM J Fregly
Nov 1, 1979·Biomedical Mass Spectrometry·J M MidgleyC M Williams
Mar 25, 2014·Drug and Chemical Toxicology·Sidney J Stohs
Mar 1, 1987·The Journal of Pharmacy and Pharmacology·C M WilliamsJ M Midgley
Jun 1, 1985·Journal of Neurochemistry·K E IbrahimJ M Midgley
Sep 1, 1987·The Journal of Pharmacy and Pharmacology·R JordanC M Williams
Sep 1, 1983·The Journal of Pharmacy and Pharmacology·M I JamesC M Williams

Related Concepts

Adrenergic alpha-Agonists
Adrenergic beta-Agonists
Metazoa
Diastolic Blood Pressure
Water Consumption
Isomerism
Novodrin
Norepinephrine, (+, -)-Isomer
Octopamine
Norepinephrine Receptors

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