Adrenergic and peptidergic regulations of hydroxyindole-O-methyltransferase activity in rat pineal gland

Brain Research
C RibelaygaV Simonneaux

Abstract

Mechanisms involved in the regulation of hydroxyindole-O-methyltransferase (HIOMT) activity were investigated in the rat pineal. Isoproterenol, db-cAMP, PACAP or VIP had no acute (6 h) effect whereas NPY, thapsigargin and a PKC activator stimulated HIOMT activity by 30-40%. Chronic stimulation (6 days) with isoproterenol, db-cAMP, or each peptide prevented the long-term decrease of HIOMT activity. Phenylephrine had neither short- nor long-term effect on enzyme activity. These results indicate that HIOMT activity is long- and short-term regulated by various neurotransmitters.

References

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Citations

Sep 28, 1998·Brain Research. Developmental Brain Research·C RibelaygaV Simonneaux
Mar 3, 1999·The European Journal of Neuroscience·V SimonneauxP Pévet
Jun 13, 2002·The European Journal of Neuroscience·Marie-Laure GaridouValérie Simonneaux
Dec 24, 2008·The Journal of Biological Chemistry·Michael J BaileyDavid C Klein
Aug 13, 2013·BioMed Research International·Cezary ChojnackiGrazyna Klupinska
Jan 7, 2016·Journal of Pineal Research·Luis Henrique Souza-TeodoroZ S Ferreira
Dec 1, 2007·Life Sciences·Rodrigo Antonio Peliciari GarciaJosé Cipolla-Neto
Jan 29, 2008·Life Sciences·Roseli BarbosaSolange Castro Afeche
Apr 24, 2014·BioMed Research International·Morten MøllerCorin Badiu
Feb 24, 2005·Journal of Pineal Research·Marie-Laure Garidou-BoofBerthe Vivien-Roels
Dec 17, 2008·Journal of Neuroendocrinology·P A C M FernandesR P Markus
May 14, 2014·Journal of Pineal Research·Fernanda G AmaralJosé Cipolla-Neto
Oct 10, 2014·International Journal of Molecular Sciences·Olga PechanovaFedor Simko
Sep 7, 2005·Cell Biochemistry and Function·Solange C AfecheJosé Cipolla-Neto
May 2, 2015·Polish Journal of Veterinary Sciences·N ZiółkowskaB Przybylska-Gornowicz
Mar 11, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Marie-Laure GaridouValerie Simonneaux
Sep 1, 1999·Microscopy Research and Technique·J D Mikkelsen, M Møller
May 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C RibelaygaV Simonneaux
Dec 18, 2002·Journal of Pineal Research·Ana-Lucia SkorupaValérie Simonneaux

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