Adrenergic innervation of pancreatic islets and modulation of insulin secretion by the sympatho-adrenal system

Cell and Tissue Research
B AhrénF Sundler

Abstract

Morphological changes in the adrenergic innervation of pancreatic islets after chemical sympathectomy by use of 6-hydroxydopamine and the influence of the sympatho-adrenal system on insulin secretion were investigated in the mouse and rat. Fluorescence histochemistry revealed a clear-cut reduction in the number of adrenergic nerve fibres in the pancreatic islets 2 days after administration of 6-hydroxydopamine; the reduction was more pronounced in the rat than in the mouse. In the rat, a partial regeneration was seen after 6 weeks. In the pancreas of the mouse, after administration of 6-hydroxydopamine, a severe damage of unmyelinated nerve fibres was revealed electron microscopically. However, no ultrastructural or immunohistochemical alterations could be demonstrated in the endocrine cells of the islets. 6-Hydroxydopamine induced a depression of basal plasma insulin concentrations in mice and an elevation in rats. Adrenalectomy depressed basal plasma insulin levels in mice. The alpha-adrenoceptor antagonist phentolamine enhanced insulin secretion in normal mice. The secretory response of insulin to phentolamine was diminished by chemical sympathectomy and almost abolished by adrenalectomy or the combination of chemical sympat...Continue Reading

Citations

May 1, 1991·Cell and Tissue Research·S LindskogF Sundler
Apr 1, 1981·Pflügers Archiv : European journal of physiology·B Ahrén, I Lundquist
Jan 1, 1982·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·P ThulH Pichlmaier
Nov 3, 1987·European Journal of Pharmacology·G SkoglundB Ahrén
Oct 23, 1990·European Journal of Pharmacology·G W JohnJ L Reid
Mar 1, 1991·Journal of the Autonomic Nervous System·S Karlsson, B Ahrén
Feb 9, 2013·Endocrinology and Metabolism Clinics of North America·Rayner Rodriguez-Diaz, Alejandro Caicedo
Jan 28, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·I GiannulisS Cinti
Jan 23, 2016·Diabetologia·Mehboob A HussainWoo-Jin Song
Jun 27, 2000·Diabetes/metabolism Research and Reviews·P Bergsten
Jan 1, 1996·Cell Transplantation·H HouwingJ H Strubbe
Nov 1, 1991·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·S Karlsson, B Ahrén

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