Adrenergic innervation of the human uterus. Disappearance of the transmitter and transmitter-forming enzymes during pregnancy

American Journal of Obstetrics and Gynecology
G ThorbertN O Sjöberg

Abstract

The uterine adrenergic transmitter is in many animal species dramatically reduced during pregnancy, probably leading to a functional denervation near term. In order to clarify whether similar changes also occur in the human uterus, the adrenergic innervation of the isthmic myometrium during nonpregnant and pregnant conditions was analyzed by fluorescence histochemistry for demonstration of adrenergic nerves, and by quantitative measurements of norepinephrine and its synthesizing enzymes, tyrosine hydroxylase and dopa decarboxylase. At term pregnancy all fluorescent adrenergic nerves in the myometrium had disappeared, and the norepinephrine concentration had been reduced to almost zero. Parallel to this the activities of tyrosine hydroxylase and dopa decarboxylase were markedly reduced. By contrast, the activity of the acetylcholine-synthesizing enzyme, choline acetyltransferase, was unchanged, indicating that the adrenergic system was selectively affected. The results confirm that the adrenergic nerves in the human uterus, like those in uterine horns of laboratory animals, undergo fundamental changes in the course of pregnancy. This probably reflects entirely different conditions for a sympathetic influence on the myometrium du...Continue Reading

Citations

Jun 6, 2003·British Journal of Pharmacology·Eva PatakFrancisco M Pinto
Mar 8, 2019·Cell Transplantation·Veronika AleksandrovychKrzysztof Gil
Jan 1, 1984·Journal of Perinatal Medicine·V Zahn
Nov 5, 1997·Annals of the New York Academy of Sciences·M Akerlund
Nov 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·I ZupkóG Falkay
Jun 14, 1990·The New England Journal of Medicine·C Rose
Mar 1, 1985·Acta Physiologica Scandinavica·G FriedI Dahlin
Jun 1, 1993·Asia-Oceania Journal of Obstetrics and Gynaecology·T OkawaH Nakanishi
Nov 29, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Melissa J WentzAyman Al-Hendy

Related Concepts

Choline O-Acetyltransferase
DOPA decarboxylase
Cytochemistry
Norepinephrine, (+, -)-Isomer
Sympathetic Nervous System
Tyrosine 3-Monooxygenase
Uterus
Neurosteroids

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