PMID: 9187524Feb 1, 1997Paper

Adrenergic modulation of hepatotoxicity

Drug Metabolism Reviews
S M RobertsR C James

Abstract

Summaries of the interactions caused by altering adrenoreceptor activity in conjunction with the administration of selected hepatotoxicants are provided in Table 2 and Fig. 1. These hepatotoxicants can be divided into two groups, one whose toxicity is increased by adrenergic agonist drugs (group I) and the other whose toxicity is decreased by adrenergic antagonists (group II). Group I includes carbon tetrachloride, acetaminophen, and methylphenidate. Perhaps the most remarkable aspect these chemicals have in common is the striking potentiation that occurs with cotreatment with certain adrenergic agonist drugs. For each of these, cotreatment with the appropriate adrenergic agent can result in massive hepatocellular necrosis from an otherwise nontoxic dose. In terms of the specific adrenoreceptors involved and mechanisms of potentiation, however, they have little in common. Potentiation of carbon tetrachloride hepatotoxicity appears to be mediated by alpha(2)-adrenoceptor stimulation, acetaminophen is potentiated by alpha(1)-adrenoreceptor agonists, and methylphenidate responds to beta(2)-adrenoreceptor stimulation. Studies of the potentiation of carbon tetrachloride and acetaminophen agree that the timing of adrenergic stimulati...Continue Reading

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Citations

Dec 12, 2007·British Journal of Pharmacology·L E RandleB K Park
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·G L Plaa
Mar 14, 2011·Molecular Informatics·Alexey LaguninVladimir Poroikov
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Dec 28, 2012·Biological & Pharmaceutical Bulletin·Katsuhiro IsodaMasakatsu Tezuka
May 17, 2021·Journal of Neural Transmission·Federico MucciDonatella Marazziti

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