Adrenergic receptor-mediated activation of FGF-21-adiponectin axis exerts atheroprotective effects in brown adipose tissue-transplanted apoE-/- mice

Biochemical and Biophysical Research Communications
Masakazu KikaiSatoaki Matoba

Abstract

Brown adipose tissue (BAT) has been found as an endocrine organ that maintains metabolic homeostasis; however, the effects on atherosclerosis remain undefined. Here, we investigated the effect of experimental BAT transplantation on atherosclerosis. Interscapular BAT was dissected from wild-type mice and transplanted into the visceral cavity of 12-week-old apoE-/- mice. Oil-red O staining of whole aortas after 3 months of a high-cholesterol diet showed a significant decrease in atherosclerotic lesion area in BAT-transplanted mice by 32% compared with the sham control mice. Lipid profiles, except for serum triglyceride level, showed no difference between the 2 groups. BAT-transplanted mice showed higher concentrations of serum noradrenalin, fibroblast growth factor 21 (FGF-21), and adiponectin. Treatment with the β3-adrenergic receptor (AR) blocker completely abrogated the atheroprotective effects of BAT transplantation, with serum concentrations of FGF-21 and adiponectin being equivalent between the 2 groups. Homologous transplantation of BAT from apoE-/- mice also showed a significant decrease in atherosclerotic lesion area by 28% without affecting lipid profiles, while epidydimal white adipose tissue transplantation did not af...Continue Reading

Citations

May 7, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yang LiuHang Yin
Jul 13, 2019·Nature Reviews. Endocrinology·Ludger Scheja, Joerg Heeren
Mar 31, 2019·Journal of Physiology and Biochemistry·Katarzyna DolegowskaBarbara Dolegowska
Sep 20, 2018·Current Hypertension Reports·Eashita DasHoon-Ki Sung
Aug 6, 2021·Archives of Plastic Surgery·Kento TakayaKazuo Kishi
Nov 30, 2021·Journal of Cardiovascular Pharmacology·Candela Diaz-Canestro, Aimin Xu

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