PMID: 11927398Apr 3, 2002Paper

Adrenergic regulation of catecholamine secretion from trout (Oncorhynchus mykiss) chromaffin cells

The Journal of Endocrinology
Colin J Montpetit, S F Perry

Abstract

The interaction between extracellular catecholamines and catecholamine secretion from chromaffin cells was assessed in rainbow trout (Oncorhynchus mykiss) using an in situ saline-perfused posterior cardinal vein preparation. This was accomplished by comparing the effects of adrenergic receptor agonists and antagonists on stimulus-evoked secretion. An acute bolus injection or extended perfusion with saline containing high levels of either noradrenaline or adrenaline did not affect the baseline secretion of catecholamines. However, catecholamine secretion in response to a bolus injection of the general cholinergic receptor agonist carbachol or electrical stimulation of the nerves innervating the chromaffin cells was abolished or reduced respectively, in preparations perfused with saline containing either catecholamine. To characterize the catecholaminergic inhibition of catecholamine release, secretion in response to carbachol and electrical stimulation was compared in preparations perfused with the adrenergic receptor agonists dobutamine (beta(1)), salbutamol (beta(2)), phenylephrine (alpha(1)) or clonidine (alpha(2)). Prior treatment with dobutamine or phenylephrine was without effect on baseline catecholamine secretion or stim...Continue Reading

Citations

Jun 7, 2011·Developmental and Comparative Immunology·Magdalena ChadzinskaB M Lidy Verburg-van Kemenade
Nov 25, 2003·Pharmacology & Toxicology·Bertil Waldeck
Jun 1, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jun FengWilliam C Aird
Jan 31, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Josep RotllantDeborah M Power

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