Adrenergic regulation of P2X3 and TRPV1 receptors: differential effects of spared nerve injury

Neuroscience Letters
Jason G MeisnerJ Sawynok

Abstract

Local application of alphabetaMeATP (ligand for P2X3 receptors) and capsaicin (ligand for TRPV1 receptors) to the rat hindpaw produces pain behaviors (flinching) which are enhanced by noradrenaline (NA). In this study, we have examined the effect of nerve injury on adrenergic regulation of P2X3 and TRPV1 receptors by administering alphabetaMeATP and capsaicin, alone and in combination with NA, into the lateral and medial hindpaw in the spared nerve injury (SNI) model; this allows for an exploration of the role of injured and uninjured afferents in their effects on nociceptive signaling using a behavioral model. Following lateral hindpaw injections (sural sensory field), effects of NA and alphabetaMeATP, both alone and in combination, were increased following SNI, but no such effects were seen following medial hindpaw injections (saphenous sensory field). Following lateral hindpaw injections, the effect of capsaicin alone was unaltered following SNI, but the effect of NA/capsaicin was reduced; this latter effect was not seen following medial hindpaw injections. At the lateral site, prazosin (alpha1-adrenergic receptor antagonist) inhibited the effect of NA/alphabetaMeATP following SNI, but neither prazosin nor GF109203X (protein...Continue Reading

References

May 2, 2001·Journal of Neurochemistry·M S RamerS B McMahon
Jun 26, 2001·The European Journal of Neuroscience·L J HudsonJ Winter
Oct 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gautam BhaveRobert W Gereau
Jan 5, 2006·Drug News & Perspectives·S McGaraughty, M F Jarvis
Feb 7, 2006·The Journal of Pain : Official Journal of the American Pain Society·Jana SawynokJason Meisner
Apr 28, 2007·Nature Reviews. Drug Discovery·Arpad SzallasiSamer R Eid
May 22, 2007·The Journal of Pain : Official Journal of the American Pain Society·Jason G MeisnerJana Sawynok

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